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Gold nanoparticle interactions with endothelial cells cultured under physiological conditions

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Freese, C., Anspach, L., Deller, Robert C., Richards, Sarah-Jane, Gibson, Matthew I., Kirkpatrick, C. J. and Unger, R. E. (2017) Gold nanoparticle interactions with endothelial cells cultured under physiological conditions. Biomaterials Science, 5 (4). pp. 707-717. doi:10.1039/C6BM00853D

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Official URL: http://dx.doi.org/10.1039/C6BM00853D

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Abstract

PEGylated gold nanoparticles (AuNPs) have an extended circulation time after intravenous injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and cancer treatment. No impact of PEGylated AuNPs on the barrier forming properties of endothelial cells (ECs) has been reported, but recent studies demonstrated that unexpected effects on erythrocytes are observed. Almost all studies to date have been with static-cultured ECs. Herein, ECs maintained under physiological cyclic stretch and flow conditions and used to generate a blood–brain barrier model were exposed to 20 nm PEGylated AuNPs. An evaluation of toxic effects, cell stress, the release profile of pro-inflammatory cytokines, and blood–brain barrier properties showed that even under physiological conditions no obvious effects of PEGylated AuNPs on ECs were observed. These findings suggest that 20 nm-sized, PEGylated AuNPs may be a useful tool for biomedical applications, as they do not affect the normal function of healthy ECs after entering the blood stream.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Nanoparticles, Endothelial cells, Gold, Biomedical materials, Metals in medicine, Erythrocytes
Journal or Publication Title: Biomaterials Science
Publisher: R S C Publications
ISSN: 2047-4830
Official Date: 1 April 2017
Dates:
DateEvent
1 April 2017Published
10 February 2017Available
30 January 2017Accepted
24 November 2016Submitted
Volume: 5
Number: 4
Page Range: pp. 707-717
DOI: 10.1039/C6BM00853D
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Engineering and Physical Sciences Research Council (EPSRC), University of Warwick. Molecular Organisation and Assembly in Cells (MOAC), Seventh Framework Programme (European Commission) (FP7)
Grant number: NMP4-CT-2006-026723 (FP7)

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