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Transporter oligomerization : form and function
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Alguel, Y., Cameron, Alexander, Diallinas, G. and Byrne, B. (2016) Transporter oligomerization : form and function. Biochemical Society Transactions, 44 (6). pp. 1737-1744. doi:10.1042/BST20160217 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST20160217
Abstract
Transporters are integral membrane proteins with central roles in the efficient movement of molecules across biological membranes. Many transporters exist as oligomers in the membrane. Depending on the individual transport protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans, have revealed both that dimerization of this protein is essential for correct trafficking to the membrane and the structural basis of how one UapA protomer can affect the function of the closely associated adjacent protomer. Here, we review the roles of oligomerization in many particularly well-studied transporters and transporter families.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Library of Congress Subject Headings (LCSH): | Oligomers, Oligomerization, Membrane proteins, Aspergillus nidulans | ||||||
Journal or Publication Title: | Biochemical Society Transactions | ||||||
Publisher: | Portland Press Ltd | ||||||
ISSN: | 0300-5127 | ||||||
Official Date: | 2 December 2016 | ||||||
Dates: |
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Volume: | 44 | ||||||
Number: | 6 | ||||||
Page Range: | pp. 1737-1744 | ||||||
DOI: | 10.1042/BST20160217 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 17 February 2017 | ||||||
Date of first compliant Open Access: | 20 February 2017 | ||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||
Grant number: | Grant BB/K017292/1 |
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