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Spread and evolution of respiratory syncytial virus A genotype ON1, coastal Kenya, 2010–2015
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Otieno, James R., Kamau, Everlyn M., Agoti, Charles N., Lewa, Clement, Otieno, Grieven, Bett, Ann, Ngama, Mwanajuma, Cane, Patricia A. and Nokes, D. James (2017) Spread and evolution of respiratory syncytial virus A genotype ON1, coastal Kenya, 2010–2015. Emerging Infectious Diseases, 23 (2). pp. 264-271. doi:10.3201/eid2302.161149 ISSN 1080-6059.
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Official URL: http://dx.doi.org/10.3201/eid2302.161149
Abstract
In February 2012, the novel respiratory syncytial virus (RSV) group A, genotype ON1, was detected in Kilifi County, coastal Kenya. ON1 is characterized by a 72-nt duplication within the highly variable G gene (encoding the immunogenic attachment surface protein). Cases were diagnosed through surveillance of pneumonia in children at the county hospital. Analysis of epidemiologic, clinical, and sequence data of RSV-A viruses detected over 5 RSV seasons (2010/2011 to 2014/2015) indicated the following: 1) replacement of previously circulating genotype GA2 by ON1, 2) an abrupt expansion in the number of ON1 variants detected in the 2014/2015 epidemic, 3) recent accumulation of amino acid substitutions within the ON1 duplicated sequence, and 4) no clear evidence of altered pathogenicity relative to GA2. The study demonstrates the public health importance of molecular surveillance in defining the spread, clinical effects, and evolution of novel respiratory virus variants.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus -- Genetic aspects -- Kilifi District (Kenya), Communicable diseases | ||||||
Journal or Publication Title: | Emerging Infectious Diseases | ||||||
Publisher: | US Department of Health and Human Services | ||||||
ISSN: | 1080-6059 | ||||||
Official Date: | February 2017 | ||||||
Dates: |
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Volume: | 23 | ||||||
Number: | 2 | ||||||
Page Range: | pp. 264-271 | ||||||
DOI: | 10.3201/eid2302.161149 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 21 February 2017 | ||||||
Date of first compliant Open Access: | 21 February 2017 | ||||||
Funder: | Wellcome Trust (London, England) | ||||||
Grant number: | Grant nos. 102975, 100542, 084633, 077092 |
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