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Lipid droplet growth : regulation of a dynamic organelle
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Barneda, David and Christian, Mark (2017) Lipid droplet growth : regulation of a dynamic organelle. Current Opinion in Cell Biology, 47 . pp. 9-15. doi:10.1016/j.ceb.2017.02.002 ISSN 0955-0674.
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WRAP_wms_cell__dev_bio-210217-wrap_cocb_review_lds_revision_mc_with_figures.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1153Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.ceb.2017.02.002
Abstract
Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. Although small LDs are observed in all types of eukaryotic cells, it is adipocytes that present the widest range of sizes up to the massive unilocular droplet of a white adipocyte. Our knowledge of the proteins and associated processes that control LD dynamics is improving. The dynamic expression of LD-associated proteins is vital for controlling LD biology and is most apparent during adipocyte differentiation. Recent findings on the molecular mechanisms of lipid droplet enlargement reveal the importance of distinct functional groups of proteins and phospholipids.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
| Library of Congress Subject Headings (LCSH): | Lipids, Cell organelles, Cell metabolism, Eukaryotic cells, Fat cells, Phospholipids | ||||||||
| Journal or Publication Title: | Current Opinion in Cell Biology | ||||||||
| Publisher: | Elsevier Science BV | ||||||||
| ISSN: | 0955-0674 | ||||||||
| Official Date: | August 2017 | ||||||||
| Dates: |
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| Volume: | 47 | ||||||||
| Page Range: | pp. 9-15 | ||||||||
| DOI: | 10.1016/j.ceb.2017.02.002 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 22 February 2017 | ||||||||
| Date of first compliant Open Access: | 21 February 2018 |
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