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The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior
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Doncom, Kay E. B., Willcock, Helen and O’Reilly, Rachel K. (2017) The direct synthesis of sulfobetaine-containing amphiphilic block copolymers and their self-assembly behavior. European Polymer Journal, 87 . pp. 497-507. doi:10.1016/j.eurpolymj.2016.09.002 ISSN 0014-3057.
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Official URL: http://dx.doi.org/10.1016/j.eurpolymj.2016.09.002
Abstract
Diblock copolymers containing the thermo-responsive sulfobetaine, [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (DMAPS), were synthesized by the aqueous RAFT polymerization of DMAPS, followed by direct chain extension in hexafluoroisopropanol (HFIP) with methyl methacrylate (MMA). This was shown to give lower dispersity polymers than RAFT emulsion polymerization. The diblock copolymers self-assembled in water to form micelles, as analyzed by light scattering (LS) and transmission electron microscopy (TEM). Micelles formed from diblocks bearing a long PDMAPS block were shown to swell with temperature, rather than display a traditional UCST cloud point. This was due to the polymers retaining hydrophilicity, even at temperatures well below the UCST for the corresponding PDMAPS homopolymer, as shown by variable temperature NMR. This swelling behavior was utilized in the release of a hydrophobic dye in response to temperature. This approach has great potential for applications in controlled release whilst maintaining the structure of the carrier nanoparticles.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Diblock copolymers -- Synthesis, Thermoresponsive polymers, Self-assembly (Chemistry), Controlled release technology | ||||||||||
Journal or Publication Title: | European Polymer Journal | ||||||||||
Publisher: | Pergamon | ||||||||||
ISSN: | 0014-3057 | ||||||||||
Official Date: | February 2017 | ||||||||||
Dates: |
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Volume: | 87 | ||||||||||
Page Range: | pp. 497-507 | ||||||||||
DOI: | 10.1016/j.eurpolymj.2016.09.002 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 27 February 2017 | ||||||||||
Date of first compliant Open Access: | 27 February 2017 | ||||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), University of Warwick | ||||||||||
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