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Synthesis and applications of protein/peptide-polymer conjugates
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Wilson, Paul (2017) Synthesis and applications of protein/peptide-polymer conjugates. Macromolecular Chemistry and Physics , 218 (9). 1600595. doi:10.1002/macp.201600595 ISSN 1022-1352.
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WRAP_0971273-ch-280217-synthesis_and_applications_of_proteinpeptide-polymer_conjugates_.pdf - Accepted Version - Requires a PDF viewer. Download (1105Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/macp.201600595
Abstract
Recent advances in synthetic methodologies have brought us closer than ever to the precision conferred by nature. For example, the control possible in reversible deactivation radical polymerization enables us to design and synthesize macromolecules with unprecedented control over not only the polymer chain ends, but also the side chain functionality. Furthermore, this functionality can be exploited to afford chemical modification of peptides and proteins, with ever-improving site-specificity, yielding a range of well-defined protein/peptide-hybrid materials. Such materials benefit from the amalgamation of the properties of proteins/peptides with those of the synthetic (macro)molecules in question. Here, the latest developments in the synthesis of functional polymers and their use for preparation of well-defined protein/peptide-polymer conjugates will be discussed, with particular attention focused on modulating the stability, efficacy and/or administration of therapeutic peptides.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
| Library of Congress Subject Headings (LCSH): | Addition polymerization, Peptides -- Synthesis, Proteins -- Synthesis | ||||||||||
| Journal or Publication Title: | Macromolecular Chemistry and Physics | ||||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||||
| ISSN: | 1022-1352 | ||||||||||
| Official Date: | May 2017 | ||||||||||
| Dates: |
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| Volume: | 218 | ||||||||||
| Number: | 9 | ||||||||||
| Article Number: | 1600595 | ||||||||||
| DOI: | 10.1002/macp.201600595 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||
| Date of first compliant deposit: | 28 February 2017 | ||||||||||
| Date of first compliant Open Access: | 27 February 2018 | ||||||||||
| Funder: | Leverhulme Trust (LT), Monash-Warwick Alliance |
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