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Synthesis and applications of protein/peptide-polymer conjugates

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Wilson, Paul (2017) Synthesis and applications of protein/peptide-polymer conjugates. Macromolecular Chemistry and Physics , 218 (9). 1600595. doi:10.1002/macp.201600595 ISSN 1022-1352.

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Official URL: http://dx.doi.org/10.1002/macp.201600595

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Abstract

Recent advances in synthetic methodologies have brought us closer than ever to the precision conferred by nature. For example, the control possible in reversible deactivation radical polymerization enables us to design and synthesize macromolecules with unprecedented control over not only the polymer chain ends, but also the side chain functionality. Furthermore, this functionality can be exploited to afford chemical modification of peptides and proteins, with ever-improving site-specificity, yielding a range of well-defined protein/peptide-hybrid materials. Such materials benefit from the amalgamation of the properties of proteins/peptides with those of the synthetic (macro)molecules in question. Here, the latest developments in the synthesis of functional polymers and their use for preparation of well-defined protein/peptide-polymer conjugates will be discussed, with particular attention focused on modulating the stability, efficacy and/or administration of therapeutic peptides.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Addition polymerization, Peptides -- Synthesis, Proteins -- Synthesis
Journal or Publication Title: Macromolecular Chemistry and Physics
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 1022-1352
Official Date: May 2017
Dates:
DateEvent
May 2017Published
27 February 2017Published
27 February 2017Accepted
16 December 2016Submitted
Volume: 218
Number: 9
Article Number: 1600595
DOI: 10.1002/macp.201600595
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 28 February 2017
Date of first compliant Open Access: 27 February 2018
Funder: Leverhulme Trust (LT), Monash-Warwick Alliance

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