Alam, Mohammad Tauqee, Medema, Marnix H, Takano, Eriko and Breitling, Rainer (2011) Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism. FEBS Letters, 585 (14). pp. 2389-94. doi:10.1016/j.febslet.2011.06.014 ISSN 0014-5793.

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Abstract

Actinomycetes are highly important bacteria. On one hand, some of them cause severe human and plant diseases, on the other hand, many species are known for their ability to produce antibiotics. Here we report the results of a comparative analysis of genome-scale metabolic models of 37 species of actinomycetes. Based on in silico knockouts we generated topological and genomic maps for each organism. Combining the collection of genome-wide models, we constructed a global enzyme association network to identify both a conserved "core network" and an "essential core network" of the entire group. As has been reported for low-degree metabolites in several organisms, low-degree enzymes (in linear pathways) turn out to be generally more essential than high-degree enzymes (in metabolic hubs).

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	FEBS Letters
Publisher:	Elsevier BV
ISSN:	0014-5793
Official Date:	22 July 2011
Dates:	Date Event 22 July 2011 Published 14 June 2011 Accepted 9 May 2011 Submitted
Volume:	585
Number:	14
Page Range:	pp. 2389-94
DOI:	10.1016/j.febslet.2011.06.014
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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