Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Functional metabolomics describes the yeast biosynthetic regulome

Tools
- Tools
+ Tools

Mülleder, Michael, Calvani, Enrica, Alam, Mohammad T., Wang, Richard Kangda, Eckerstorfer, Florian, Zelezniak, Aleksej and Ralser, Markus (2016) Functional metabolomics describes the yeast biosynthetic regulome. Cell, 167 (2). 553-565.e12.

[img]
Preview
PDF
WRAP_PIIS0092867416312375_.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (4Mb) | Preview
Official URL: http://dx.doi.org/10.1016/j.cell.2016.09.007

Request Changes to record.

Abstract

Genome-metabolism interactions enable cell growth. To probe the extent of these interactions and delineate their functional contributions, we quantified the Saccharomyces amino acid metabolome and its response to systematic gene deletion. Over one-third of coding genes, in particular those important for chromatin dynamics, translation, and transport, contribute to biosynthetic metabolism. Specific amino acid signatures characterize genes of similar function. This enabled us to exploit functional metabolomics to connect metabolic regulators to their effectors, as exemplified by TORC1, whose inhibition in exponentially growing cells is shown to match an interruption in endomembrane transport. Providing orthogonal information compared to physical and genetic interaction networks, metabolomic signatures cluster more than half of the so far uncharacterized yeast genes and provide functional annotation for them. A major part of coding genes is therefore participating in gene-metabolism interactions that expose the metabolism regulatory network and enable access to an underexplored space in gene function.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QK Botany
Q Science > QP Physiology
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Yeast -- Genetic aspects, Saccharomyces -- Genetic aspects, Metabolites
Journal or Publication Title: Cell
Publisher: Cell Press
ISSN: 1097-4172
Official Date: 6 October 2016
Dates:
DateEvent
6 October 2016Published
29 September 2016Available
2 September 2016Accepted
23 October 2015Submitted
Volume: 167
Number: 2
Page Range: 553-565.e12
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Francis Crick Institute, Cancer Research UK (CRUK), Medical Research Council (Great Britain) (MRC), Wellcome Trust (London, England), European Research Council (ERC), European Commission (EC), Marie Skłodowska-Curie actions
Grant number: FC001134 (CRUK), FC001134 (MRC), FC001134, RG093735/Z/10/Z, 200829/Z/16/Z (Wellcome Trust), Grant 260809 (ERC), ALTF-969 2014 (EC), LTFCOFUND2013 GA-2013-609409 (Marie Skłodowska-Curie actions)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us