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Impaired visual short-term memory capacity is distinctively associated with structural connectivity of the posterior thalamic radiation and the splenium of the corpus callosum in preterm-born adults
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Menegaux, Aurore, Meng, Chun, Neitzel, Julia, Bäuml, Josef G., Müller, Hermann J., Bartmann, Peter, Wolke, Dieter, Wohlschläger, Afra M., Finke, Kathrin and Sorg, Christian (2017) Impaired visual short-term memory capacity is distinctively associated with structural connectivity of the posterior thalamic radiation and the splenium of the corpus callosum in preterm-born adults. NeuroImage, 150 . pp. 68-76. doi:10.1016/j.neuroimage.2017.02.017 ISSN 1053-8119.
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Official URL: http://dx.doi.org/10.1016/j.neuroimage.2017.02.017
Abstract
Preterm birth is associated with an increased risk for lasting changes in both the cortico-thalamic system and attention; however, the link between cortico-thalamic and attention changes is as yet little understood. In preterm newborns, cortico-cortical and cortico-thalamic structural connectivity are distinctively altered, with increased local clustering for cortico-cortical and decreased integrity for cortico-thalamic connectivity. In preterm-born adults, among the various attention functions, visual short-term memory (vSTM) capacity is selectively impaired. We hypothesized distinct associations between vSTM capacity and the structural integrity of cortico-thalamic and cortico-cortical connections, respectively, in preterm-born adults.
A whole-report paradigm of briefly presented letter arrays based on the computationally formalized Theory of Visual Attention (TVA) was used to quantify parameter vSTM capacity in 26 preterm- and 21 full-term-born adults. Fractional anisotropy (FA) of posterior thalamic radiations and the splenium of the corpus callosum obtained by diffusion tensor imaging were analyzed by tract-based spatial statistics and used as proxies for cortico-thalamic and cortico-cortical structural connectivity.
The relationship between vSTM capacity and cortico-thalamic and cortico-cortical connectivity, respectively, was significantly modified by prematurity. In full-term-born adults, the higher FA in the right posterior thalamic radiation the higher vSTM capacity; in preterm-born adults this FA-vSTM-relationship was inversed. In the splenium, higher FA was correlated with higher vSTM capacity in preterm-born adults, whereas no significant relationship was evident in full-term-born adults.
These results indicate distinct associations between cortico-thalamic and cortico-cortical integrity and vSTM capacity in preterm-and full-term-born adults. Data suggest compensatory cortico-cortical fiber re-organization for attention deficits after preterm delivery.
Item Type: | Journal Article | ||||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Premature infants , Short-term memory, Child development , Attention | ||||||||||
Journal or Publication Title: | NeuroImage | ||||||||||
Publisher: | Elsevier | ||||||||||
ISSN: | 1053-8119 | ||||||||||
Official Date: | 15 April 2017 | ||||||||||
Dates: |
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Volume: | 150 | ||||||||||
Page Range: | pp. 68-76 | ||||||||||
DOI: | 10.1016/j.neuroimage.2017.02.017 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 6 March 2017 | ||||||||||
Date of first compliant Open Access: | 15 April 2018 | ||||||||||
Funder: | Marie Curie Training Network , Deutsche Forschungsgemeinschaft (DFG), China Scholarship Council (CSC), Germany. Bundesministerium für Bildung und Forschung (BMBF), Technische Universität München. Kommission für Klinische Forschung (KKF) | ||||||||||
Grant number: | ITN-2013-606901 (Marie Curie Training Network), FI1424/2, SO1336/1-1 (DFG), No: 2010604026 (CSC), 01ER0801, 01EV0710, 01ER0803 (BMBF), 8765162 (KKF) |
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