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Passive diastolic modelling of human ventricles : effects of base movement and geometrical heterogeneity
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Palit, Arnab, Franciosa, Pasquale, Bhudia, Sunil K., Arvanitis, Theodoros N., Turley, Glen A. and Williams, Mark A. (Antony) (2017) Passive diastolic modelling of human ventricles : effects of base movement and geometrical heterogeneity. Journal of Biomechanics, 52 . pp. 95-105. doi:10.1016/j.jbiomech.2016.12.023 ISSN 0021-9290.
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Official URL: http://dx.doi.org/10.1016/j.jbiomech.2016.12.023
Abstract
Left-ventricular (LV) remodelling, associated with diastolic heart failure, is driven by an increase in myocardial stress. Therefore, normalisation of LV wall stress is the cornerstone of many therapeutic treatments. However, information regarding such regional stress–strain for human LV is still limited. Thus, the objectives of our study were to determine local diastolic stress–strain field in healthy LVs, and consequently, to identify the regional variations amongst them due to geometric heterogeneity. Effects of LV base movement on diastolic model predictions, which were ignored in the literature, were further explored. Personalised finite-element modelling of five normal human bi-ventricles was carried out using subject-specific myocardium properties. Model prediction was validated individually through comparison with end-diastolic volume and a new shape-volume based measurement of LV cavity, extracted from magnetic resonance imaging. Results indicated that incorporation of LV base movement improved the model predictions (shape-volume relevancy of LV cavity), and therefore, it should be considered in future studies. The LV endocardium always experienced higher fibre stress compared to the epicardium for all five subjects. The LV wall near base experienced higher stress compared to equatorial and apical locations. The lateral LV wall underwent greater stress distribution (fibre and sheet stress) compared to other three regions. In addition, normal ranges of different stress–strain components in different regions of LV wall were reported for five healthy ventricles. This information could be used as targets for future computational studies to optimise diastolic heart failure treatments or design new therapeutic interventions/devices.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | ||||||||
| Library of Congress Subject Headings (LCSH): | Heart -- Left ventricle -- Mechanical properties, Heart failure | ||||||||
| Journal or Publication Title: | Journal of Biomechanics | ||||||||
| Publisher: | Pergamon Press | ||||||||
| ISSN: | 0021-9290 | ||||||||
| Official Date: | 8 February 2017 | ||||||||
| Dates: |
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| Volume: | 52 | ||||||||
| Page Range: | pp. 95-105 | ||||||||
| DOI: | 10.1016/j.jbiomech.2016.12.023 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 9 March 2017 | ||||||||
| Date of first compliant Open Access: | 29 December 2017 | ||||||||
| Funder: | Warwick Manufacturing Group |
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