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Chemical probing of thiotetronate bio-assembly
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Havemann, Judith, Yurkovich, Marie E., Jenkins, Robert, Harringer, Sophia, Tao, Weixin, Wen, Shishi, Sun, Yuhui, Leadlay, P. F. and Tosin, Manuela (2017) Chemical probing of thiotetronate bio-assembly. Chemical Communications, 53 (11). pp. 1912-1915. doi:10.1039/C6CC09933E ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C6CC09933E
Abstract
Chemical ‘chain termination’ probes were utilised for the investigation of thiotetronate antibiotic biosynthesis in the filamentous bacteria Lentzea sp. and Streptomyces thiolactonus NRRL 15439. The use of these tools led to the capture of biosynthetic intermediates involved in the thiotetronate polyketide backbone assembly, providing first insights into substrate specificity and in vivo intermediate processing by unusual iterative synthases.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Polyketides, Metabolites, Antibiotics, Antitubercular agents, Antimalarials, Trypanosomiasis | |||||||||||||||
Journal or Publication Title: | Chemical Communications | |||||||||||||||
Publisher: | Royal Society of Chemistry | |||||||||||||||
ISSN: | 1359-7345 | |||||||||||||||
Official Date: | 2017 | |||||||||||||||
Dates: |
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Volume: | 53 | |||||||||||||||
Number: | 11 | |||||||||||||||
Page Range: | pp. 1912-1915 | |||||||||||||||
DOI: | 10.1039/C6CC09933E | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 13 March 2017 | |||||||||||||||
Date of first compliant Open Access: | 13 March 2017 | |||||||||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), ERASMUS (Organization), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC) | |||||||||||||||
Grant number: | BB/J007250/1 (BBSRC), Grant 31300061 (NSFC) | |||||||||||||||
RIOXX Funder/Project Grant: |
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