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Gauging circadian variation in ketamine metabolism by real-time breath analysis
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Martinez-Lozano Sinues, P., Kohler, M., Brown, S. A., Zenobi, R. and Dallmann, Robert (2017) Gauging circadian variation in ketamine metabolism by real-time breath analysis. Chemical Communications, 53 (14). pp. 2264-2267. doi:10.1039/C6CC09061C ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C6CC09061C
Abstract
The time-of-day of drug application is an important factor in maximizing efficacy and minimizing toxicity. Real-time in vivo mass spectrometric breath analysis of mice was deployed to investigate time-of-day variation in ketamine metabolism. Different production rates of ketamine metabolites, including the recently described anti-depressant hydroxynorketamine, were found in opposite circadian phases. Thus, breath analysis has potential as a rapid and 3Rs (Replacement, Reduction and Refinement) conforming screening method to estimate the time-dependence of drug metabolism.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RD Surgery |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
Library of Congress Subject Headings (LCSH): | Ketamine -- Metabolism, Respiration, Circadian rhythms | ||||||||
Journal or Publication Title: | Chemical Communications | ||||||||
Publisher: | Royal Society of Chemistry | ||||||||
ISSN: | 1359-7345 | ||||||||
Official Date: | 2 February 2017 | ||||||||
Dates: |
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Volume: | 53 | ||||||||
Number: | 14 | ||||||||
Page Range: | pp. 2264-2267 | ||||||||
DOI: | 10.1039/C6CC09061C | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 20 March 2017 | ||||||||
Date of first compliant Open Access: | 2 February 2018 | ||||||||
Funder: | Marie Curie European Reintegration Grants (ERG), Seventh Framework Programme (European Commission) (FP7), UniversitätsSpital Zürich | ||||||||
Grant number: | 276860 (FP7) |
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