UNSPECIFIED (2003) Chimeric pneumovirus nucleocapsid (N) proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein. JOURNAL OF GENERAL VIROLOGY, 84 (Part 10). pp. 2679-2683. doi:10.1099/vir.0.19370-0

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Abstract

The nucleocapsid (N) protein of the pneumovirus respiratory syncytial virus (RSV) is a major structural protein which encapsidates the RNA genome and is essential for replication and transcription of the RSV genome. The N protein of the related virus pneumonia virus of mice (PVM) is functionally unable to replace the RSV N protein in a minigenome replication assay. Using chimeric proteins, in which the immediate C-terminal part of the RSV N protein was replaced with the equivalent region of the PVM N protein, it was shown that six amino acid residues near the C terminus of the N protein (between residues 352-369) are essential for its function in replication and for the ability of the N protein to bind to the viral phosphoprotein, P.

Item Type:	Journal Article
Subjects:	T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF GENERAL VIROLOGY
Publisher:	SOC GENERAL MICROBIOLOGY
ISSN:	0022-1317
Official Date:	October 2003
Dates:	Date Event October 2003 UNSPECIFIED
Volume:	84
Number:	Part 10
Number of Pages:	5
Page Range:	pp. 2679-2683
DOI:	10.1099/vir.0.19370-0
Publication Status:	Published

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