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Chimeric pneumovirus nucleocapsid (N) proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein
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UNSPECIFIED (2003) Chimeric pneumovirus nucleocapsid (N) proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein. JOURNAL OF GENERAL VIROLOGY, 84 (Part 10). pp. 2679-2683. doi:10.1099/vir.0.19370-0
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Official URL: http://dx.doi.org/10.1099/vir.0.19370-0
Abstract
The nucleocapsid (N) protein of the pneumovirus respiratory syncytial virus (RSV) is a major structural protein which encapsidates the RNA genome and is essential for replication and transcription of the RSV genome. The N protein of the related virus pneumonia virus of mice (PVM) is functionally unable to replace the RSV N protein in a minigenome replication assay. Using chimeric proteins, in which the immediate C-terminal part of the RSV N protein was replaced with the equivalent region of the PVM N protein, it was shown that six amino acid residues near the C terminus of the N protein (between residues 352-369) are essential for its function in replication and for the ability of the N protein to bind to the viral phosphoprotein, P.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology |
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| Journal or Publication Title: | JOURNAL OF GENERAL VIROLOGY | ||||
| Publisher: | SOC GENERAL MICROBIOLOGY | ||||
| ISSN: | 0022-1317 | ||||
| Official Date: | October 2003 | ||||
| Dates: |
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| Volume: | 84 | ||||
| Number: | Part 10 | ||||
| Number of Pages: | 5 | ||||
| Page Range: | pp. 2679-2683 | ||||
| DOI: | 10.1099/vir.0.19370-0 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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