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The effects of different aspirin dosing frequencies and the timing of aspirin intake in primary and secondary prevention of cardiovascular disease : a systematic review
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Bem, D., Lordkipanidzé, M., Hodgkinson, J., Stevens, S., Bayliss, S., Moore, D., Fitzmaurice, D. A. and Dretzke, J. (2016) The effects of different aspirin dosing frequencies and the timing of aspirin intake in primary and secondary prevention of cardiovascular disease : a systematic review. Clinical Pharmacology & Therapeutics, 100 (5). pp. 500-512. doi:10.1002/cpt.438 ISSN 0009-9236.
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Official URL: http://dx.doi.org/10.1002/cpt.438
Abstract
Enhancing the effectiveness of aspirin by tailoring administration regimens is an important question among health professionals. We conducted a systematic review to evaluate the evidence on the effects of different aspirin regimens in terms of timing (chronotherapy) or frequency of dosing in the prevention of cardiovascular disease. Only two out of the 28 included studies reported long-term cardiovascular outcomes, highlighting an evidence gap that future research should address. The remaining 26 studies used surrogate outcomes.
| Item Type: | Journal Article | ||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Clinical Pharmacology & Therapeutics | ||||||
| Publisher: | American Society for Clinical Pharmacology and Therapeutics | ||||||
| ISSN: | 0009-9236 | ||||||
| Official Date: | 19 September 2016 | ||||||
| Dates: |
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| Volume: | 100 | ||||||
| Number: | 5 | ||||||
| Page Range: | pp. 500-512 | ||||||
| DOI: | 10.1002/cpt.438 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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