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The effects of different aspirin dosing frequencies and the timing of aspirin intake in primary and secondary prevention of cardiovascular disease : a systematic review

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Bem, D., Lordkipanidzé, M., Hodgkinson, J., Stevens, S., Bayliss, S., Moore, D., Fitzmaurice, D. A. and Dretzke, J. (2016) The effects of different aspirin dosing frequencies and the timing of aspirin intake in primary and secondary prevention of cardiovascular disease : a systematic review. Clinical Pharmacology & Therapeutics, 100 (5). pp. 500-512. doi:10.1002/cpt.438 ISSN 0009-9236.

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Official URL: http://dx.doi.org/10.1002/cpt.438

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Abstract

Enhancing the effectiveness of aspirin by tailoring administration regimens is an important question among health professionals. We conducted a systematic review to evaluate the evidence on the effects of different aspirin regimens in terms of timing (chronotherapy) or frequency of dosing in the prevention of cardiovascular disease. Only two out of the 28 included studies reported long-term cardiovascular outcomes, highlighting an evidence gap that future research should address. The remaining 26 studies used surrogate outcomes.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Clinical Pharmacology & Therapeutics
Publisher: American Society for Clinical Pharmacology and Therapeutics
ISSN: 0009-9236
Official Date: 19 September 2016
Dates:
DateEvent
19 September 2016Available
15 July 2016Accepted
Volume: 100
Number: 5
Page Range: pp. 500-512
DOI: 10.1002/cpt.438
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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