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Relations between effects and structure of small bicyclic molecules on the complex model system saccharomyces cerevisiae

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Brilli, Matteo, Trabocchi, Andrea, Weil, Tobias, Cavalieri, Duccio and Stefanini, Irene (2017) Relations between effects and structure of small bicyclic molecules on the complex model system saccharomyces cerevisiae. Frontiers in Pharmacology, 8 . 170. doi:10.3389/fphar.2017.00170

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Official URL: http://dx.doi.org/10.3389/fphar.2017.00170

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Abstract

The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a relatively simple system to explore the relations among chemical variance and bioactivity. To identify relations between the chemical features of the molecules and their activity, we delved into the effects of a library of small compounds on the viability of a set of S. cerevisiae strains. Thanks to the high degree of chemical diversity of the tested compounds and to the measured effect on the yeast growth rate, we were able to scale-down the chemical library and to gain information on the most effective structures at the substituent level. Our results represent a valuable source for the selection, rational design, and optimization of bioactive compounds.

Item Type: Journal Article
Subjects: Q Science > QK Botany
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Drug development, Saccharomyces cerevisiae -- Molecular aspects, Principal components analysis, High throughput screening (Drug development)
Journal or Publication Title: Frontiers in Pharmacology
Publisher: Frontiers Research Foundation
ISSN: 1663-9812
Official Date: 30 March 2017
Dates:
DateEvent
30 March 2017Published
14 March 2017Accepted
Volume: 8
Article Number: 170
DOI: 10.3389/fphar.2017.00170
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Wellcome Trust (London, England), University of Warwick

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