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Inter-arm difference in systolic blood pressure in different ethnic groups and relationship to the "white coat effect" : a cross sectional study

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Schwartz , C. L., Clark , C. E., Koshiaris, C., Gill, Paramjit, Greenfield, S. M., Haque, M. S., Heer, G., Johal, Amanpreet, Kaur, R., Mant, J., Martin, U., Mohammed, M. A., Wood, S. and McManus, R. J. (2017) Inter-arm difference in systolic blood pressure in different ethnic groups and relationship to the "white coat effect" : a cross sectional study. American Journal of Hypertension . ISSN 0895-7061.

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Official URL: https://doi.org/10.1093/ajh/hpx073

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Abstract

Background
Inter-arm differences (IAD) ≥10mmHg in systolic blood pressure (BP) are associated with greater
incidence of cardiovascular disease. The effect of ethnicity and the white coat effect (WCE) on
significant systolic inter-arm differences (ssIADs) are not well understood.
Methods
Differences in BP by ethnicity for different methods of BP measurement were examined in 770
people (300 White British, 241 South Asian, 229 African-Caribbean). Repeated clinic measurements
were obtained simultaneously in the right and left arm using two BP-Tru monitors and comparisons
made between the first reading, mean of second and third and mean of second to sixth readings for
patients with, and without known hypertension. All patients had ambulatory monitoring (ABPM).
WCE was defined as systolic Clinic BP ≥10mmHg higher than daytime ABPM.
Results
No significant differences were seen in the prevalence of ssIAD between ethnicities whichever
combinations of BP measurement were used and regardless of hypertensive status. ssIADs fell
between the 1st measurement (161, 22%), 2
nd/3
rd (113, 16%) and 2
nd
-6
th (78, 11%) (1st vs 2
nd/3
rd and
2
nd
-6
th, p<0.001). Hypertensives with a WCE were more likely to have ssIADs on 1st, (OR 1.73 (95% CI
1.04-2.86), 2
nd/3
rd
, (OR 3.05 (1.68-5.53) and 2nd
-6
th measurements, (OR 2.58 (1.22-5.44). Nonhypertensive
participants with a WCE were more likely to have a ssIAD on their first measurement
(OR 3.82 (1.77 -8.25) only.
Conclusion
ssIAD prevalence does not vary with ethnicity regardless of hypertensive status but is affected by the
number of readings, suggesting the influence of WCE. Multiple readings should be used to confirm
ssIADs

Item Type: Journal Article
Alternative Title:
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: American Journal of Hypertension
Publisher: Oxford University Press
ISSN: 0895-7061
Official Date: 5 May 2017
Dates:
DateEvent
5 May 2017Published
5 April 2017Accepted
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 6 April 2017
Date of first compliant Open Access: 5 May 2018

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