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Inherited predisposition to preeclampsia : analysis of the Aberdeen intergenerational cohort
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Ayorinde, Abimbola and Bhattacharya, Sohinee (2017) Inherited predisposition to preeclampsia : analysis of the Aberdeen intergenerational cohort. Pregnancy Hypertension : An International Journal of Women's Cardiovascular Health, 8 . pp. 37-41. doi:10.1016/j.preghy.2017.03.001
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Official URL: http://dx.doi.org/10.1016/j.preghy.2017.03.001
Abstract
Objective
To assess the magnitude of familial risk of preeclampsia and gestational hypertension in women born of a preeclamptic pregnancy and those born of pregnancy complicated by gestational hypertension while accounting for other risk factors.
Methods
An intergenerational dataset was extracted from the Aberdeen Maternity and Neonatal Databank (AMND) which records all pregnancy and delivery details occurring in Aberdeen, Scotland since 1950. The analysis included all nulliparous women whose mothers’ records at their births are also recorded in the AMND. Multinomial logistic regression was used to assess the risk of having preeclampsia or gestational hypertension based on maternal history of preeclampsia or gestational hypertension.
Results
There were 17302 nulliparous women included, of whom 1057(6.1%) had preeclampsia while 4098(23.7%) had gestational hypertension. Furthermore, 424(2.5%) and 2940(17.0%) had maternal history of preeclampsia and gestational hypertension respectively. The risk of preeclampsia was higher in women who were born of pregnancies complicated by preeclampsia (adjusted RRR 2.55 95% CI 1.87–3.47). This was higher than the risk observed in women whose mothers had gestational hypertension (adjusted RRR 1.44 95% CI 1.23–1.69). Conversely, the risk of gestational hypertension was similar in those who were born of preeclamptic pregnancies (adjusted RRR 1.37 95% CI 1.09–1.71) and those whose mothers had gestational hypertension (adjusted RRR 1.36 95% CI 1.24–1.49).
Conclusion
There was a dose response effect in the inheritance pattern of preeclampsia with the highest risk in women born of preeclamptic pregnancies. Gestational hypertension showed similar increased risk with maternal gestational hypertension and preeclampsia.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Pregnancy Hypertension : An International Journal of Women's Cardiovascular Health | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 2210-7789 | ||||||||
| Official Date: | April 2017 | ||||||||
| Dates: |
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| Volume: | 8 | ||||||||
| Page Range: | pp. 37-41 | ||||||||
| DOI: | 10.1016/j.preghy.2017.03.001 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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