UNSPECIFIED. (2004) Acute rejection after renal transplantation is reduced by approximately 50% by prior therapeutic blood transfusions, even in tacrolimus-treated patients. TRANSPLANTATION, 77 (3). pp. 469-471. ISSN 0041-1337

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Abstract

Background. The authors investigated the relationship between therapeutic blood transfusion before renal transplantation and rejection rates in cyclosporine- and tacrolimus-treated patients. Methods. In one center, 265 consecutive recipients were studied. Protocol induction was with azathioprine, prednisolone, and cyclosporine or tacrolimus; 37% had biopsy-proven acute rejection in the first 6 months and 46% had received zero to two units of blood before transplantation. Results. Lower risk of rejection was associated with tacrolimus induction (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.29-0.95; P=0.049), prior transfusion of three or more units of blood (OR, 0.54; 95% CI, 0.33-0.90; P=0.024), and older age at transplantation (mean, 44.23 +/- 2.56 [+/-SD] years vs. 38.96 +/- 12.37 years; P=0.001). Multiple logistic regression modeling showed the effect of three or more prior transfusions on acute rejection was as follows: OR, 0.49; 95% CI, 0.29 to 0.83; P=0.008. Conclusions. Induction immunosuppression should take account of the higher risk of rejection in patients coming to transplantation who have previously received zero to two units of blood.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RD Surgery
Journal or Publication Title:	TRANSPLANTATION
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
ISSN:	0041-1337
Date:	15 February 2004
Volume:	77
Number:	3
Number of Pages:	3
Page Range:	pp. 469-471
Identification Number:	10.1016/01.TP.0000111756.83834.A7
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/8753

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