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Acute rejection after renal transplantation is reduced by approximately 50% by prior therapeutic blood transfusions, even in tacrolimus-treated patients
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UNSPECIFIED. (2004) Acute rejection after renal transplantation is reduced by approximately 50% by prior therapeutic blood transfusions, even in tacrolimus-treated patients. TRANSPLANTATION, 77 (3). pp. 469-471. ISSN 0041-1337
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Official URL: http://dx.doi.org/10.1016/01.TP.0000111756.83834.A...
Abstract
Background. The authors investigated the relationship between therapeutic blood transfusion before renal transplantation and rejection rates in cyclosporine- and tacrolimus-treated patients.
Methods. In one center, 265 consecutive recipients were studied. Protocol induction was with azathioprine, prednisolone, and cyclosporine or tacrolimus; 37% had biopsy-proven acute rejection in the first 6 months and 46% had received zero to two units of blood before transplantation.
Results. Lower risk of rejection was associated with tacrolimus induction (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.29-0.95; P=0.049), prior transfusion of three or more units of blood (OR, 0.54; 95% CI, 0.33-0.90; P=0.024), and older age at transplantation (mean, 44.23 +/- 2.56 [+/-SD] years vs. 38.96 +/- 12.37 years; P=0.001). Multiple logistic regression modeling showed the effect of three or more prior transfusions on acute rejection was as follows: OR, 0.49; 95% CI, 0.29 to 0.83; P=0.008.
Conclusions. Induction immunosuppression should take account of the higher risk of rejection in patients coming to transplantation who have previously received zero to two units of blood.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RD Surgery |
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| Journal or Publication Title: | TRANSPLANTATION | ||||
| Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||
| ISSN: | 0041-1337 | ||||
| Official Date: | 15 February 2004 | ||||
| Dates: |
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| Volume: | 77 | ||||
| Number: | 3 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 469-471 | ||||
| Identification Number: | 10.1016/01.TP.0000111756.83834.A7 | ||||
| Publication Status: | Published | ||||
| URI: | http://wrap.warwick.ac.uk/id/eprint/8753 |
Data sourced from Thomson Reuters' Web of Knowledge
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