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Environmental reservoirs of pathogenic mycobacteria across the Ethiopian biogeographical landscape
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King, Hayley C., Khera-Butler , Tanya, James, Phillip, Oakley, Brian B., Erenso, Girume, Aseffa, Abraham, Knight, Robert, Wellington, E. M. H. and Courtenay, Orin (2017) Environmental reservoirs of pathogenic mycobacteria across the Ethiopian biogeographical landscape. PLoS One, 12 (3). e0173811. doi:10.1371/journal.pone.0173811 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0173811
Abstract
The Mycobacterium genus comprises over one-hundred-and-fifty recognised species, the majority of which reside in the environment and many of which can be pathogenic to mammals. Some species of environmental mycobacteria may interfere with BCG vaccination efficacy and in tuberculin test interpretation. Examining biogeographic trends in the distribution of members of the mycobacteria across a number of physicochemical and spatial gradients in soil and water environments across Ethiopia using oligotyping identified differential distributions of pathogenic and significant species. The tuberculosis complex was identified in more than 90% of water samples and taxonomic groups implicated in lower BCG vaccine efficiency were core in both soil and water Mycobacterium communities. A reservoir of Mycobacterium bovis was identified in water, with up to 7.3×102 genome equivalents per ml. Elevation, temperature, habitat and vegetation type were important predictors of both soil and water Mycobacterium communities. These results represent the first step in understanding the potential risk of exposure to environmental mycobacteria that may undermine efforts to reduce disease incidence.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Mycobacteria -- Ethiopia, Pathogenic bacteria, BCG vaccination, Medicine, Preventive | ||||||||
Journal or Publication Title: | PLoS One | ||||||||
Publisher: | Public Library of Science | ||||||||
ISSN: | 1932-6203 | ||||||||
Official Date: | 23 March 2017 | ||||||||
Dates: |
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Volume: | 12 | ||||||||
Number: | 3 | ||||||||
Article Number: | e0173811 | ||||||||
DOI: | 10.1371/journal.pone.0173811 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 7 April 2017 | ||||||||
Date of first compliant Open Access: | 7 April 2017 | ||||||||
Funder: | Natural Environment Research Council (Great Britain) (NERC) |
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