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The roles of the orbitofrontal cortex via the habenula in non-reward and depression, and in the responses of serotonin and dopamine neurons

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Rolls, Edmund T. (2017) The roles of the orbitofrontal cortex via the habenula in non-reward and depression, and in the responses of serotonin and dopamine neurons. Neuroscience & Biobehavioral Reviews, 75 . pp. 331-334. doi:10.1016/j.neubiorev.2017.02.013

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Official URL: http://dx.doi.org/10.1016/j.neubiorev.2017.02.013

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Abstract

Cortical regions such as the orbitofrontal cortex involved in reward and in non-reward and which are implicated in depression, and the amygdala, are connected to the habenula via the striatum and pallidum, and via subcortical limbic structures. The habenula in turn projects to the raphe nuclei, the source of the serotonin-containing neurons that project to the forebrain. It is proposed that this provides a route for cortical signals related to reward, and to not obtaining expected rewards, to influence the serotonin-containing neuronal system that is influenced by many antidepressant treatments. This helps to provide a more circuit-based understanding of the brain mechanisms related to depression, and how some treatments influence this system. The habenula also projects via the rostromedial tegmental nucleus to the dopamine-containing neurons, and this, it is proposed, provides a route for reward prediction error signals and other reward- and punishment-related signals of cortical and striatal origin to influence the dopamine system.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH): Prefrontal cortex, Brain, Depression, Mental , Serotonin , Dopamine, Computational neuroscience
Journal or Publication Title: Neuroscience & Biobehavioral Reviews
Publisher: Pergamon
ISSN: 0149-7634
Official Date: April 2017
Dates:
DateEvent
April 2017Published
14 February 2017Available
12 February 2017Accepted
Volume: 75
Page Range: pp. 331-334
DOI: 10.1016/j.neubiorev.2017.02.013
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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