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Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition

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Deng, Wanlu, Rolls, Edmund T., Ji, Xiaoxi, Robbins, Trevor W., Banaschewski, Tobias, Bokde, Arun L. W., Bromberg, Uli, Buechel, Christian, Desrivières, Sylvane, Conrod, Patricia et al.
(2017) Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition. Human Brain Mapping, 38 (7). pp. 3527-3537.

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Official URL: https://doi.org/10.1002/hbm.23607

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Abstract

To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop-signal task, in 1709 participants. First, areas activated more in stop-success than stop-failure included the lateral orbitofrontal cortex extending into the inferior frontal gyrus (ventrolateral prefrontal cortex, BA 47/12), and the dorsolateral prefrontal cortex. Second, the anterior cingulate and anterior insula were activated more on failure trials, specifically in stop-failure vs stop-success. The interaction between brain region and stop-success vs stop-failure activations was significant (p = 5.6 * 10-8). The results provide new evidence from this ‘big data’ investigation consistent with the hypotheses that the lateral orbitofrontal cortex is involved in the stop-related processing that inhibits the action; that the dorsolateral prefrontal cortex is involved in attentional processes that influence task performance; and that the anterior insula and anterior cingulate are involved in emotional processes when failure occurs. The investigation thus emphasizes the role of the human lateral orbitofrontal cortex BA 47/12 in changing behavior, and inhibiting behavior when necessary. A very similar area in BA47/12 is involved in changing behavior when an expected reward is not obtained, and has been shown to have high functional connectivity in depression.

Item Type: Journal Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Computer Science
Library of Congress Subject Headings (LCSH): Brain mapping, Prefrontal cortex -- Physiology, Behavior modification, Computational neuroscience
Journal or Publication Title: Human Brain Mapping
Publisher: John Wiley and Sons
ISSN: 1065-9471
Official Date: July 2017
Dates:
DateEvent
July 2017Published
21 April 2017Available
27 March 2017Accepted
Volume: 38
Number: 7
Page Range: pp. 3527-3537
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS), Sixth Framework Programme (European Commission) (FP6), Seventh Framework Programme (European Commission) (FP7), Innovative Medicines Initiative (IMI), Medical Research Council (Great Britain) (MRC), Sweden. Vetenskapsrådet [Research Council], Wellcome Trust (London, England), National Institute for Health Research (Great Britain) (NIHR), Maudsley NHS Foundation Trust, King’s College London, Germany. Bundesministerium für Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), France. Agence nationale de la recherche (ANR), Fondation de France (FF), Fondation pour la recherche médicale (FRM), France‏. Mission interministérielle de lutte contre les drogues et les conduites addictives‏, Hôpitaux de Paris, Institut national de la santé et de la recherche médicale (France) (INSERM), Université Paris-Sud, National Institutes of Health (U.S.) (NIH)
Grant number: 91230201 (NSFC), 2015AA02050 (CAS), 11101429 (NSFC), 11471081(NSFC), LSHM-CT-2007-037286 (FP6), 602450 (FP7), 602805 (FP7), 603016 (FP7), 115300-2 (IMI), 93558 (MRC), MR/N000390/1(MRC), 01GS08152 (BMBF); 01EV0711 (BMBF); eMED SysAlc01ZX1311A (BMBF),
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIED[RS] Royal Society. Wolfson Research Merit Award (RSWRMA)http://dx.doi.org/10.13039/501100000288
91230201Guo jia zi ran ke xue ji jin wei yuan hui [NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
2015AA02050Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS)UNSPECIFIED
LSHM-CT-2007-037286Sixth Framework Programmehttp://dx.doi.org/10.13039/100011103
602450Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
115300-2innovative Medicines Initiative [IMI]UNSPECIFIED
93558[MRC] Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDSweden. Vetenskapsrådet [Research Council]UNSPECIFIED
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100010269
UNSPECIFIED[NIHR] National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDMaudsley NHS Foundation TrustUNSPECIFIED
UNSPECIFIEDKings College Londonhttp://dx.doi.org/10.13039/501100000764
01GS08152Germany. Bundesministerium für Bildung und Forschung [BMBF]UNSPECIFIED
UNSPECIFIED[DFG] Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
UNSPECIFIED[ANR] Agence Nationale de la Recherchehttp://dx.doi.org/10.13039/501100001665
UNSPECIFIEDFondation de Francehttp://dx.doi.org/10.13039/501100004431
UNSPECIFIEDFondation pour la recherche médicale (FRM)UNSPECIFIED
UNSPECIFIEDFrance. Mission interministérielle de lutte contre les drogues et les conduites addictivesUNSPECIFIED
UNSPECIFIEDHôpitaux de ParisUNSPECIFIED
UNSPECIFIEDInstitut national de la santé et de la recherche médicale (France) (INSERM)http://dx.doi.org/10.13039/501100001677
UNSPECIFIEDUniversité Paris-Sudhttp://dx.doi.org/10.13039/501100007486
UNSPECIFIEDNational Institutes of Healthhttp://dx.doi.org/10.13039/100000002
11101429Guo jia zi ran ke xue ji jin wei yuan hui [NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
11471081Guo jia zi ran ke xue ji jin wei yuan hui [NSFC] National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
602805Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
603016Seventh Framework Programmehttp://dx.doi.org/10.13039/100011102
01EV0711Germany. Bundesministerium für Bildung und Forschung [BMBF]http://dx.doi.org/10.13039/501100002347
eMED SysAlc01ZX1311AGermany. Bundesministerium für Bildung und Forschung [BMBF]http://dx.doi.org/10.13039/501100002347

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