The Library
Outcome measures used in arthroplasty trials : systematic review of the 2008 and 2013 literature
Tools
Tools
Tools
Richards, Bethan, Wall, Peter D. H., Sprowson, Andrew P., Singh, Jasvinder and Buchdbinder, Rachelle (2017) Outcome measures used in arthroplasty trials : systematic review of the 2008 and 2013 literature. The Journal of Rheumatology, 44 (8). pp. 1277-1287. doi:10.3899/jrheum.161477 ISSN 0315-162X.
|
PDF
WRAP-outcome-measures-arthroplasty-trials-Wall-2017.pdf - Accepted Version - Requires a PDF viewer. Download (2121Kb) | Preview |
Official URL: https://doi.org/10.3899/jrheum.161477
Abstract
Background/objective: Previously published literature assessing the reporting of outcome measures used in joint replacement randomised controlled trials (RCTs) has revealed disappointing results. It remains unknown as to whether international initiatives have led to any improvement in the quality of reporting and/or a reduction in the heterogeneity of outcome measures used. Our objective was to systematically assess and compare primary outcome measures and risk of bias of joint replacement RCTs published in 2008 and 2013. Methods: We searched MEDLINE, EMBASE and CENTRAL for RCTs investigating adult patients undergoing joint replacement surgery. Two authors independently identified eligible trials, extracted data and assessed risk of bias using the Cochrane tool. Results: Seventy RCTs (30 in 2008; 40 in 2013) met the eligibility criteria. There was no significant difference in the number of trials judged to be at low overall risk of bias (N=6, 20%) in 2008 compared with six (15%) in 2013 (χ2 =0.302, P=0.75). Significantly more trials published in 2008 did not specify a primary outcome measure (N=25, 83%) compared with 18 (45%) trials in 2013, χ2 = 10.6316, P=0.001). When specified, there was significant heterogeneity in the measures used to assess primary outcomes. Conclusion: While less than a quarter of trials published in both 2008 and 2013 were judged to be at low overall risk of bias, significantly more trials published in 2013 specified a primary outcome. Although this might represent a temporal trend towards improvement, the overall frequency of primary outcome reporting and the wide heterogeneity in primary outcomes reported remain suboptimal.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RD Surgery | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||
| Library of Congress Subject Headings (LCSH): | Arthroplasty, Joints -- Surgery | ||||||
| Journal or Publication Title: | The Journal of Rheumatology | ||||||
| Publisher: | Journal of Rheumatology Publishing Co. Ltd. | ||||||
| ISSN: | 0315-162X | ||||||
| Official Date: | 1 August 2017 | ||||||
| Dates: |
|
||||||
| Volume: | 44 | ||||||
| Number: | 8 | ||||||
| Page Range: | pp. 1277-1287 | ||||||
| DOI: | 10.3899/jrheum.161477 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 10 April 2017 | ||||||
| Date of first compliant Open Access: | 1 September 2018 |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
