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Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana
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Prince, David C., Rallapalli, Ghanasyam, Xu, Deyang, Schoonbeek, Henk-jan, Cevik, Volkan, Asai, Shuta, Kemen, Eric, Cruz-Mireles, Neftaly, Kemen, Ariane C., Belhaj, Khaoula, Schornack, Sebastian, Kamoun, Sophien, Holub, E. B., Halkier, Barbara A. and Jones, Jonathan D. G. (2017) Albugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thaliana. BMC Biology, 15 (20). 360. doi:10.1186/s12915-017-0360-z
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Official URL: http://dx.doi.org/10.1186/s12915-017-0360-z
Abstract
BACKGROUND:
Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent colonization by any given member of a pathogen species. White blister rust caused by Albugo species can overcome non-host resistance and enable secondary infection and reproduction of usually non-virulent pathogens, including the potato late blight pathogen Phytophthora infestans on Arabidopsis thaliana. However, the molecular basis of host defense suppression in this complex plant-microbe interaction is unclear. Here, we investigate specific defense mechanisms in Arabidopsis that are suppressed by Albugo infection.
RESULTS:
Gene expression profiling revealed that two species of Albugo upregulate genes associated with tryptophan-derived antimicrobial metabolites in Arabidopsis. Albugo laibachii-infected tissue has altered levels of these metabolites, with lower indol-3-yl methylglucosinolate and higher camalexin accumulation than uninfected tissue. We investigated the contribution of these Albugo-imposed phenotypes to suppression of non-host resistance to P. infestans. Absence of tryptophan-derived antimicrobial compounds enables P. infestans colonization of Arabidopsis, although to a lesser extent than Albugo-infected tissue. A. laibachii also suppresses a subset of genes regulated by salicylic acid; however, salicylic acid plays only a minor role in non-host resistance to P. infestans.
CONCLUSIONS:
Albugo sp. alter tryptophan-derived metabolites and suppress elements of the responses to salicylic acid in Arabidopsis. Albugo sp. imposed alterations in tryptophan-derived metabolites may play a role in Arabidopsis non-host resistance to P. infestans. Understanding the basis of non-host resistance to pathogens such as P. infestans could assist in development of strategies to elevate food security.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | S Agriculture > SB Plant culture | ||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Plant immunology, Plants -- Disease and pest resistance, Albugo candida, Arabidopsis thaliana, Plant-pathogen relationships | ||||||
| Journal or Publication Title: | BMC Biology | ||||||
| Publisher: | BioMed Central Ltd. | ||||||
| ISSN: | 1741-7007 | ||||||
| Official Date: | 20 March 2017 | ||||||
| Dates: |
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| Volume: | 15 | ||||||
| Number: | 20 | ||||||
| Article Number: | 360 | ||||||
| DOI: | 10.1186/s12915-017-0360-z | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | European Research Council (ERC), Gatsby Foundation, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Danmarks Grundforskningsfond [Danish National Research Foundation], Nihon Gakujutsu ShinkÅkai [Japan Society for the Promotion of Science] (NGS) | ||||||
| Grant number: | 233376, BB/G042960/1, 99 |
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