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Anaphylaxis and ethnicity : higher incidence in British South Asians
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Buka, R. J., Crossman, Richard, Melchior, C. L., Huissoon, A. P., Hackett, S., Dorrian, S., Cooke, Matthew and Krishna, Mamidipudi (2015) Anaphylaxis and ethnicity : higher incidence in British South Asians. Allergy, 70 (12). pp. 1580-1587. doi:10.1111/all.12702 ISSN 0105-4538.
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Official URL: http://dx.doi.org/10.1111/all.12702
Abstract
BACKGROUND:
The incidence of anaphylaxis in South Asians (Indian, Pakistani and Bangladeshi ethnicity) is unknown. Birmingham is a British city with a disproportionately large population of South Asians (22.5%) compared with the rest of the UK (4.9%). The main aims of this study were to determine the incidence and severity of anaphylaxis in this population and to investigate the differences between the South Asian and White populations.
METHODS:
A retrospective electronic search of emergency department attendances at three hospitals in Birmingham during 2012 was carried out. Wide search terms were used, medical notes were scrutinized, and the World Allergy Organization diagnostic criteria for anaphylaxis were applied. Patients' age, sex, ethnicity and home postal code were collected, reactions were graded by severity, and other relevant details including specialist assessment were extracted. Multivariate analysis was undertaken using 2011 UK census data.
RESULTS:
Age-, sex- and ethnicity-standardized incidence rate of anaphylaxis was 34.5 per 100 000 person-years. Multivariate logistic regression which controlled for the confounders of age, sex and level of socioeconomic deprivation showed that incidence was higher in the South Asian population (OR 1.48, P = 0.005). Incidence rate in the South Asian population was 58.3 cases per 100 000 person-years compared to 31.5 in the White population. South Asian children were more likely to present with severe anaphylaxis (OR 5.31, P = 0.002).
CONCLUSIONS:
Incidence of anaphylaxis is significantly higher in British South Asians compared to the white population. British South Asian children are at a greater risk of severe anaphylaxis than White children.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Allergy | ||||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
ISSN: | 0105-4538 | ||||||||
Official Date: | December 2015 | ||||||||
Dates: |
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Volume: | 70 | ||||||||
Number: | 12 | ||||||||
Page Range: | pp. 1580-1587 | ||||||||
DOI: | 10.1111/all.12702 | ||||||||
Status: | Peer Reviewed | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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