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iLIR@viral : a web resource for LIR motif-containing proteins in viruses
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Jacomin, Anne-Claire, Samavedam, Siva, Charles, Hannah and Nezis, Ioannis P. (2017) iLIR@viral : a web resource for LIR motif-containing proteins in viruses. Autophagy, 13 (10). pp. 1782-1789. doi:10.1080/15548627.2017.1356978 ISSN 1554-8627.
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Official URL: http://dx.doi.org/10.1080/15548627.2017.1356978
Abstract
Autophagy has been shown to mediate the lysosomal degradation of pathogenic bacteria and viruses (xenophagy), and to contribute to the activation of innate and adaptative immune responses. Autophagy can serve as an antiviral defense mechanism but also as a proviral process during infection. ATG8-family proteins play a central role in the autophagy process due to their ability to interact with components of the autophagy machinery as well as selective autophagy receptors and adaptor proteins. Such interactions are usually mediated through LC3-interacting region (LIR) motifs. So far, only one viral protein has been experimentally shown to have a functional LIR motif, leaving open a vast field for investigation. Here, we have developed the iLIR@viral database (http://ilir.uk/virus/) as a freely accessible web resource listing all the putative canonical LIR motifs identified in viral proteins. Additionally, we used a curated text-mining analysis of the literature to identify novel putative LIR motif-containing protein (LICRPs) in viruses. We anticipate that iLIR@viral will assist with elucidating the full complement of LIRCPs in viruses.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Library of Congress Subject Headings (LCSH): | Autophagic vacuoles, Cell death, Protein folding, Autophagy, Apoptosis, Immune response, Inflammation, Viruses, Biology -- Research | ||||||
Journal or Publication Title: | Autophagy | ||||||
Publisher: | Taylor & Francis Inc. | ||||||
ISSN: | 1554-8627 | ||||||
Official Date: | 14 August 2017 | ||||||
Dates: |
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Volume: | 13 | ||||||
Number: | 10 | ||||||
Page Range: | pp. 1782-1789 | ||||||
DOI: | 10.1080/15548627.2017.1356978 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Date of first compliant deposit: | 27 April 2017 | ||||||
Date of first compliant Open Access: | 29 March 2018 | ||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||
Grant number: | BB/L006324/1, BB/P007856/1 |
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