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Tsapras, Panagiotis and Nezis, Ioannis P. (2017) Caspase involvement in autophagy. Cell Death & Differentiation, 24 (8). pp. 1369-1379. doi:10.1038/cdd.2017.43
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Official URL: http://doi.org/10.1038/cdd.2017.43
Abstract
Caspases are a family of cysteine proteases widely known as the principal mediators of the apoptotic cell death response, but considerably less so as the contributors to the regulation of pathways outside cellular demise. In regards to autophagy, the modulatory roles of caspases have only recently begun to be adequately described. In contrast to apoptosis, autophagy promotes cell survival by providing energy and nutrients through the lysosomal degradation of cytoplasmic constituents. Under basal conditions autophagy and apoptosis cross-regulate each other through an elaborate network of interconnections which also includes the interplay between autophagyrelated proteins (ATGs) and caspases. In this review we focus on the effects of this crosstalk at the cellular level, as we aim to concentrate the main observations from research conducted so far on the fine-tuning of autophagy by caspases. Several members of this protease-family have been found to directly interact with key ATGs involved in different tiers across the autophagic cascade. Therefore, we firstly outline the core mechanism of macroautophagy in brief. In an effort to emphasize the importance of the intricate cross-regulation of ATGs and caspases, we also present examples drawn from Drosophila and plant models regarding the contribution of autophagy to apoptotic cell death during normal development.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QH Natural history | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Apoptosis, Cell death, Cysteine proteinases | ||||||||
| Journal or Publication Title: | Cell Death & Differentiation | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 1350-9047 | ||||||||
| Official Date: | August 2017 | ||||||||
| Dates: |
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| Volume: | 24 | ||||||||
| Number: | 8 | ||||||||
| Page Range: | pp. 1369-1379 | ||||||||
| DOI: | 10.1038/cdd.2017.43 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||||
| Grant number: | BB/L006324/1, BB/P007856/1 | ||||||||
| Related URLs: |
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