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Assays to monitor aggrephagy in Drosophila brain

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Jacomin, Anne-Claire and Nezis, Ioannis P. (2017) Assays to monitor aggrephagy in Drosophila brain. In: Turksen, K., (ed.) Autophagy in Differentiation and Tissue Maintenance. Methods in Molecular Biology, 1854 . New York, NY: Humana Press, pp. 147-157. ISBN 9781493987474

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Official URL: https://doi.org/10.1007/7651_2018_157

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Abstract

Accumulation of ubiquitinated protein aggregates is a hallmark of most ageingrelated neurodegenerative disorders. Autophagy has been found to be involved in the selective clearance of these protein aggregates, and this process is called aggrephagy. Here we provide two protocols for the investigation of protein aggregation and their removal by autophagy using western blotting and immunofluorescence techniques in Drosophila brain. Investigating the role of aggrephagy at the cellular and organismal level is important for the development of therapeutic interventions against ageing-related diseases.

Item Type: Book Item
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Cell death, Proteins, Drosophila -- Physiological aspects
Series Name: Methods in Molecular Biology
Journal or Publication Title: Methods in Molecular Biology
Publisher: Humana Press
Place of Publication: New York, NY
ISBN: 9781493987474
ISSN: 1064-3745
Book Title: Autophagy in Differentiation and Tissue Maintenance
Editor: Turksen, K.
Official Date: 5 June 2017
Dates:
DateEvent
5 June 2017Available
25 March 2017Accepted
Volume: 1854
Page Range: pp. 147-157
DOI: 10.1007/7651_2018_157
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 28 April 2017
Date of first compliant Open Access: 5 June 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/L006324/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/P007856/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
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