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Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces
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Carpenter, Byron and Tate, Christopher G. (2017) Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces. Current Opinion in Structural Biology, 45 . pp. 124-132. doi:10.1016/j.sbi.2017.04.010 ISSN 0959-440X.
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Official URL: https://doi.org/10.1016/j.sbi.2017.04.010
Abstract
G protein-coupled receptors (GPCRs) regulate cellular signalling through heterotrimeric G proteins and arrestins in response to an array of extracellular stimuli. Structure determination of GPCRs in an active conformation bound to intracellular signalling proteins has proved to be highly challenging. Nonetheless, three new structures of GPCRs in an active state have been published during the last year, namely the adenosine A2A receptor (A2AR) bound to an engineered G protein, opsin bound to visual arrestin and the m opioid receptor (mOR) bound to a G protein-mimicking nanobody. These structures have provided novel insight into the sequence of events leading to GPCR activation, and have highlighted both similarities and differences in the structure of the interface between GPCRs and different signalling proteins.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
| Library of Congress Subject Headings (LCSH): | G proteins -- Receptors., Molecular biology. | ||||||||||||
| Journal or Publication Title: | Current Opinion in Structural Biology | ||||||||||||
| Publisher: | Elsevier | ||||||||||||
| ISSN: | 0959-440X | ||||||||||||
| Official Date: | August 2017 | ||||||||||||
| Dates: |
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| Volume: | 45 | ||||||||||||
| Page Range: | pp. 124-132 | ||||||||||||
| DOI: | 10.1016/j.sbi.2017.04.010 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
| Copyright Holders: | Elsevier | ||||||||||||
| Date of first compliant deposit: | 9 May 2017 | ||||||||||||
| Date of first compliant Open Access: | 5 May 2018 | ||||||||||||
| Funder: | Medical Research Council (Great Britain) (MRC), European Research Council (ERC), Heptares Therapeutics (Firm) | ||||||||||||
| Grant number: | MC_U105197215; EMPSI 339995 | ||||||||||||
| RIOXX Funder/Project Grant: |
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