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Novel functions for Dorsocrossin epithelial morphogenesis in the beetle Tribolium castaneum
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Horn, Thorsten and Panfilio, Kristen A. (2016) Novel functions for Dorsocrossin epithelial morphogenesis in the beetle Tribolium castaneum. Development , 143 (16). pp. 3002-3011. doi:10.1242/dev.133280 ISSN 0950-1991.
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Official URL: http://dx.doi.org/10.1242/dev.133280
Abstract
Epithelial morphogenesis, the progressive restructuring of tissue sheets, is fundamental to embryogenesis. In insects, not only embryonic tissues but also extraembryonic (EE) epithelia play a crucial role in shaping the embryo. In Drosophila, the T-box transcription factor Dorsocross (Doc) is essential for EE tissue maintenance and therefore embryo survival. However, Drosophila possesses a single amnioserosa, whereas most insects have a distinct amnion and serosa. How does this derived situation compare with Doc function in the ancestral context of two EE epithelia? Here, we investigate the Doc orthologue in the red flour beetle, Tribolium castaneum, which is an excellent model for EE tissue complement and for functional, fluorescent live imaging approaches. Surprisingly, we find that Tc-Doc controls all major events in Tribolium EE morphogenesis without affecting EE tissue specification or maintenance. These macroevolutionary changes in function between Tribolium and Drosophila are accompanied by regulatory network changes, where BMP signaling and possibly the transcription factor Hindsight are downstream mediators. We propose that the ancestral role of Doc was to control morphogenesis and discuss how Tc-Doc could provide spatial precision for remodeling the amnion-serosa border.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | Development | ||||||
| Publisher: | The Company of Biologists Ltd. | ||||||
| ISSN: | 0950-1991 | ||||||
| Official Date: | 2016 | ||||||
| Dates: |
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| Volume: | 143 | ||||||
| Number: | 16 | ||||||
| Page Range: | pp. 3002-3011 | ||||||
| DOI: | 10.1242/dev.133280 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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