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A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production
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Oyebolu, Folarin B., Van Lidth de Jeude, Jeroen, Siganporia, Cyrus, Farid, Suzanne S., Allmendinger, Richard and Branke, Jürgen (2017) A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production. Journal of Heuristics, 23 (4). pp. 231-256. doi:10.1007/s10732-017-9338-9
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Official URL: http://doi.org/10.1007/s10732-017-9338-9
Abstract
Biopharmaceutical manufacturing requires high investments and long-term production planning. For large biopharmaceutical companies, planning typically involves multiple products and several production facilities. Production is usually done in batches with a substantial set-up cost and time for switching between products. The goal is to satisfy demand while minimising manufacturing, set-up and inventory costs. The resulting production planning problem is thus a variant of the capacitated lot-sizing and scheduling problem, and a complex combinatorial optimisation problem. Inspired by genetic algorithm approaches to job shop scheduling, this paper proposes a tailored construction heuristic that schedules demands of multiple products sequentially across several facilities to build a multi-year production plan (solution). The sequence in which the construction heuristic schedules the different demands is optimised by a genetic algorithm. We demonstrate the effectiveness of the approach on a biopharmaceutical lot sizing problem and compare it with a mathematical programming model from the literature. We show that the genetic algorithm can outperform the mathematical programming model for certain scenarios because the discretisation of time in mathematical programming artificially restricts the solution space.
| Item Type: | Journal Article | ||||||
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| Subjects: | H Social Sciences > HD Industries. Land use. Labor | ||||||
| Divisions: | Faculty of Science > Centre for Complexity Science Faculty of Social Sciences > Warwick Business School > Operational Research & Management Sciences Faculty of Social Sciences > Warwick Business School |
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| Library of Congress Subject Headings (LCSH): | Pharmaceutical biotechnology industry, Pharmaceutical biotechnology industry -- Risk management, Heuristic algorithms, Production scheduling, Production planning | ||||||
| Journal or Publication Title: | Journal of Heuristics | ||||||
| Publisher: | Springer New York LLC | ||||||
| ISSN: | 1381-1231 | ||||||
| Official Date: | 29 May 2017 | ||||||
| Dates: |
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| Date of first compliant deposit: | 10 May 2017 | ||||||
| Volume: | 23 | ||||||
| Number: | 4 | ||||||
| Number of Pages: | 27 | ||||||
| Page Range: | pp. 231-256 | ||||||
| DOI: | 10.1007/s10732-017-9338-9 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
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