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A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production

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Oyebolu, Folarin B., Van Lidth de Jeude, Jeroen, Siganporia, Cyrus, Farid, Suzanne S., Allmendinger, Richard and Branke, Jürgen (2017) A new lot sizing and scheduling heuristic for multi-site biopharmaceutical production. Journal of Heuristics, 23 (4). pp. 231-256. doi:10.1007/s10732-017-9338-9 ISSN 1381-1231.

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Official URL: http://doi.org/10.1007/s10732-017-9338-9

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Abstract

Biopharmaceutical manufacturing requires high investments and long-term production planning. For large biopharmaceutical companies, planning typically involves multiple products and several production facilities. Production is usually done in batches with a substantial set-up cost and time for switching between products. The goal is to satisfy demand while minimising manufacturing, set-up and inventory costs. The resulting production planning problem is thus a variant of the capacitated lot-sizing and scheduling problem, and a complex combinatorial optimisation problem. Inspired by genetic algorithm approaches to job shop scheduling, this paper proposes a tailored construction heuristic that schedules demands of multiple products sequentially across several facilities to build a multi-year production plan (solution). The sequence in which the construction heuristic schedules the different demands is optimised by a genetic algorithm. We demonstrate the effectiveness of the approach on a biopharmaceutical lot sizing problem and compare it with a mathematical programming model from the literature. We show that the genetic algorithm can outperform the mathematical programming model for certain scenarios because the discretisation of time in mathematical programming artificially restricts the solution space.

Item Type: Journal Article
Subjects: H Social Sciences > HD Industries. Land use. Labor
Divisions: Faculty of Science, Engineering and Medicine > Research Centres > Centre for Complexity Science
Faculty of Social Sciences > Warwick Business School > Operational Research & Management Sciences
Faculty of Social Sciences > Warwick Business School
Library of Congress Subject Headings (LCSH): Pharmaceutical biotechnology industry, Pharmaceutical biotechnology industry -- Risk management, Heuristic algorithms, Production scheduling, Production planning
Journal or Publication Title: Journal of Heuristics
Publisher: Springer New York LLC
ISSN: 1381-1231
Official Date: 29 May 2017
Dates:
DateEvent
29 May 2017Published
9 May 2017Accepted
Volume: 23
Number: 4
Number of Pages: 27
Page Range: pp. 231-256
DOI: 10.1007/s10732-017-9338-9
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 10 May 2017
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