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A systematic review and meta-analysis on the incubation period of Campylobacteriosis
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Awofisayo-Okuyelu, A., Hall, I., Adak, G., Hawker, J. I., Abbott, Susan and McCarthy, Noel D. (2017) A systematic review and meta-analysis on the incubation period of Campylobacteriosis. Epidemiology and Infection, 145 (11). pp. 2241-2253. doi:10.1017/S0950268817001303 ISSN 0950-2688.
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Official URL: https://doi.org/10.1017/S0950268817001303
Abstract
Accurate knowledge of pathogen incubation period is essential to inform public health policies and implement interventions that contribute to the reduction of burden of disease. The incubation period distribution of campylobacteriosis is currently unknown with several sources reporting different times. Variation in the distribution could be expected due to host, transmission vehicle, and organism characteristics, however, the extent of this variation and influencing factors are unclear. The authors have undertaken a systematic review of published literature of outbreak studies with well-defined point source exposures and human experimental studies to estimate the distribution of incubation period and also identify and explain the variation in the distribution between studies. We tested for heterogeneity using I 2 and Kolmogorov–Smirnov tests, regressed incubation period against possible explanatory factors, and used hierarchical clustering analysis to define subgroups of studies without evidence of heterogeneity. The mean incubation period of subgroups ranged from 2·5 to 4·3 days. We observed variation in the distribution of incubation period between studies that was not due to chance. A significant association between the mean incubation period and age distribution was observed with outbreaks involving only children reporting an incubation of 1·29 days longer when compared with outbreaks involving other age groups.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QR Microbiology | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Campylobacter infections, Systematic reviews (Medical research) | |||||||||||||||||||||
Journal or Publication Title: | Epidemiology and Infection | |||||||||||||||||||||
Publisher: | Cambridge University Press | |||||||||||||||||||||
ISSN: | 0950-2688 | |||||||||||||||||||||
Official Date: | August 2017 | |||||||||||||||||||||
Dates: |
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Volume: | 145 | |||||||||||||||||||||
Number: | 11 | |||||||||||||||||||||
Page Range: | pp. 2241-2253 | |||||||||||||||||||||
DOI: | 10.1017/S0950268817001303 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||
Date of first compliant deposit: | 6 June 2017 | |||||||||||||||||||||
Date of first compliant Open Access: | 18 January 2018 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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