Wong, Hin Kwan, Tiffin, Paul A., Chappell, Michael J., Nichols, Thomas E., Welsh, Patrick R., Doyle, Orla M., Lopez Kolkovska, Boryana Cristina, Inglis, Sarah K., Coghill, David, Shen, Yuan and Tiño, Peter (2017) Personalized medication response prediction for attention-deficit hyperactivity disorder : learning in the model space vs. learning in the data space. Frontiers in Physiology, 8 . 199. doi:10.3389/fphys.2017.00199 ISSN 1664-042X.

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Abstract

Attention-Deficit Hyperactive Disorder (ADHD) is one of the most common mental health disorders amongst school-aged children with an estimated prevalence of 5% in the global population (American Psychiatric Association, 2013). Stimulants, particularly methylphenidate (MPH), are the first-line option in the treatment of ADHD (Reeves and Schweitzer, 2004; Dopheide and Pliszka, 2009) and are prescribed to an increasing number of children and adolescents in the US and the UK every year (Safer et al., 1996; McCarthy et al., 2009), though recent studies suggest that this is tailing off, e.g., Holden et al. (2013). Around 70% of children demonstrate a clinically significant treatment response to stimulant medication (Spencer et al., 1996; Schachter et al., 2001; Swanson et al., 2001; Barbaresi et al., 2006). However, it is unclear which patient characteristics may moderate treatment effectiveness. As such, most existing research has focused on investigating univariate or multivariate correlations between a set of patient characteristics and the treatment outcome, with respect to dosage of one or several types of medication. The results of such studies are often contradictory and inconclusive due to a combination of small sample sizes, low-quality data, or a lack of available information on covariates. In this paper, feature extraction techniques such as latent trait analysis were applied to reduce the dimension of on a large dataset of patient characteristics, including the responses to symptom-based questionnaires, developmental health factors, demographic variables such as age and gender, and socioeconomic factors such as parental income. We introduce a Bayesian modeling approach in a “learning in the model space” framework that combines existing knowledge in the literature on factors that may potentially affect treatment response, with constraints imposed by a treatment response model. The model is personalized such that the variability among subjects is accounted for by a set of subject-specific parameters. For remission classification, this approach compares favorably with conventional methods such as support vector machines and mixed effect models on a range of performance measures. For instance, the proposed approach achieved an area under receiver operator characteristic curve of 82–84%, compared to 75–77% obtained from conventional regression or machine learning (“learning in the data space”) methods.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group)
SWORD Depositor:	Library Publications Router
Journal or Publication Title:	Frontiers in Physiology
Publisher:	Frontiers Research Foundation
ISSN:	1664-042X
Official Date:	11 April 2017
Dates:	Date Event 11 April 2017 Published 17 March 2017 Accepted
Volume:	8
Article Number:	199
DOI:	10.3389/fphys.2017.00199
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)

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