Synthesis of precursors of poly(acryl amides) by copper mediated living radical polymerization in DMSO
UNSPECIFIED. (2004) Synthesis of precursors of poly(acryl amides) by copper mediated living radical polymerization in DMSO. EUROPEAN POLYMER JOURNAL, 40 (1). pp. 37-45. ISSN 0014-3057Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.eurpolymj.2003.08.003
The paper describes the optimization of copper(l) mediated living radical polymerization of N-hydroxysuccinimide methacrylate to achieve AB block copoly(acryl amides) offering a route to polymers with potential biomedical applications. Polymerization of N-hydroxysuccinimide methacrylate was carried out using copper(I) bromide/N-(n-propyl)2-pyridylmethanimine catalyst with ethyl-2-bromoisobutyrate as the initiator at three different temperatures (70, 50 and 30 degreesC). Polymerizations at both 70 and 50 degreesC gave relatively high conversion, 72% and 62% respectively after 4 h. Polymerization at 30 degreesC the best linear first-order kinetic plot. The polydispersity remained narrow (1.15) and there was a good agreement between experimental, determined by H-1 NMR, and theoretical M-n. Polymerization of N-hydroxysuccinimide methacrylate was investigated in more detail by following reactions in situ by H-1 NMR. The experimental values of M-n (NMR) were quite close to the theoretical values and the polydispersities were relatively narrow (1.10-1.19). Isolated poly(N-hydroxysuceinimide methacrylate) was used as a macroinitiator for the polymerization of MMA catalyzed by Cu(I)Br in conjunction with N-(n-propyl)-2-pyridylmethanamine ligand leading to block copolymers. A poly(methyl acryl amide) is synthesized indirectly from the reaction of benzyl amine with poly(N-hydroxysuccinimide methacrylate) for 5 h with in DMSO at 50 degreesC under nitrogen. (C) 2003 Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||EUROPEAN POLYMER JOURNAL|
|Publisher:||PERGAMON-ELSEVIER SCIENCE LTD|
|Number of Pages:||9|
|Page Range:||pp. 37-45|
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