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Patient-specific, multi-scale modeling of neointimal hyperplasia in vein grafts
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Donadoni, Francesca, Pichardo-Almarza, Cesar, Bartlett, Matthew, Dardik, Alan, Homer-Vanniasinkam, Shervanthi and Díaz-Zuccarini, Vanessa (2017) Patient-specific, multi-scale modeling of neointimal hyperplasia in vein grafts. Frontiers in Physiology, 8 . 226. doi:10.3389/fphys.2017.00226 ISSN 1664-042X.
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Official URL: https://doi.org/10.3389/fphys.2017.00226
Abstract
Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease, particularly with regard to mechanical stimuli due to shear stresses on the vessel wall. By combining a biochemical model of cell growth and a patient-specific computational fluid dynamics analysis of blood flow in the lumen, remodeling of the blood vessel is studied by means of a novel computational framework. The framework was used to analyze two vein graft bypasses from one patient: a femoro-popliteal and a femoro-distal bypass. The remodeling of the vessel wall and analysis of the flow for each case was then compared to clinical data and discussed as a potential tool for a better understanding of the disease. Simulation results from this first computational approach showed an overall agreement on the locations of hyperplasia in these patients and demonstrated the potential of using new integrative modeling tools to understand disease progression.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RB Pathology R Medicine > RD Surgery |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Veins -- Transplantation, Hyperplasia -- Mathematical models | ||||||
Journal or Publication Title: | Frontiers in Physiology | ||||||
Publisher: | Frontiers Research Foundation | ||||||
ISSN: | 1664-042X | ||||||
Official Date: | 18 April 2017 | ||||||
Dates: |
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Volume: | 8 | ||||||
Article Number: | 226 | ||||||
DOI: | 10.3389/fphys.2017.00226 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 15 September 2017 | ||||||
Date of first compliant Open Access: | 15 September 2017 | ||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Leverhulme Trust (LT). Senior Research Fellowship | ||||||
Grant number: | EP/L001101/1, EP/L000296/1) (EPSRC), RF-2015-482 (Leverhulme Trust (LT). Senior Research Fellowship) |
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