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Scaffolds for 3D in vitro culture of neural lineage cells.

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Murphy, Ashley R., Laslett, Andrew, O'Brien, Carmel M. and Cameron, Neil R. (2017) Scaffolds for 3D in vitro culture of neural lineage cells. Acta Biomaterialia, 54 . pp. 1-20. doi:10.1016/j.actbio.2017.02.046 ISSN 1742-7061.

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Official URL: http://dx.doi.org/10.1016/j.actbio.2017.02.046

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Abstract

Understanding how neurodegenerative disorders develop is not only a key challenge for researchers but also for the wider society, given the rapidly aging populations in developed countries. Advances in this field require new tools with which to recreate neural tissue in vitro and produce realistic disease models. This in turn requires robust and reliable systems for performing 3D in vitro culture of neural lineage cells. This review provides a state of the art update on three-dimensional culture systems for in vitro development of neural tissue, employing a wide range of scaffold types including hydrogels, solid porous polymers, fibrous materials and decellularised tissues as well as microfluidic devices and lab-on-a-chip systems. To provide some context with in vivo development of the central nervous system (CNS), we also provide a brief overview of the neural stem cell niche, neural development and neural differentiation in vitro. We conclude with a discussion of future directions for this exciting and important field of biomaterials research.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Nervous system -- Degeneration -- Treatment, Neural stem cells, Developmental neurobiology, Human cell culture, Tissue scaffolds
Journal or Publication Title: Acta Biomaterialia
Publisher: Elsevier Science Ltd.
ISSN: 1742-7061
Official Date: May 2017
Dates:
DateEvent
May 2017Published
1 March 2017Available
28 February 2017Accepted
Volume: 54
Page Range: pp. 1-20
DOI: 10.1016/j.actbio.2017.02.046
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 6 June 2017
Date of first compliant Open Access: 7 June 2017

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