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Scaffolds for 3D in vitro culture of neural lineage cells.
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Murphy, Ashley R., Laslett, Andrew, O'Brien, Carmel M. and Cameron, Neil R. (2017) Scaffolds for 3D in vitro culture of neural lineage cells. Acta Biomaterialia, 54 . pp. 1-20. doi:10.1016/j.actbio.2017.02.046
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Official URL: http://dx.doi.org/10.1016/j.actbio.2017.02.046
Abstract
Understanding how neurodegenerative disorders develop is not only a key challenge for researchers but also for the wider society, given the rapidly aging populations in developed countries. Advances in this field require new tools with which to recreate neural tissue in vitro and produce realistic disease models. This in turn requires robust and reliable systems for performing 3D in vitro culture of neural lineage cells. This review provides a state of the art update on three-dimensional culture systems for in vitro development of neural tissue, employing a wide range of scaffold types including hydrogels, solid porous polymers, fibrous materials and decellularised tissues as well as microfluidic devices and lab-on-a-chip systems. To provide some context with in vivo development of the central nervous system (CNS), we also provide a brief overview of the neural stem cell niche, neural development and neural differentiation in vitro. We conclude with a discussion of future directions for this exciting and important field of biomaterials research.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science > Engineering | ||||||||
| Library of Congress Subject Headings (LCSH): | Nervous system -- Degeneration -- Treatment, Neural stem cells, Developmental neurobiology, Human cell culture, Tissue scaffolds | ||||||||
| Journal or Publication Title: | Acta Biomaterialia | ||||||||
| Publisher: | Elsevier Science Ltd. | ||||||||
| ISSN: | 1742-7061 | ||||||||
| Official Date: | May 2017 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 6 June 2017 | ||||||||
| Volume: | 54 | ||||||||
| Page Range: | pp. 1-20 | ||||||||
| DOI: | 10.1016/j.actbio.2017.02.046 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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