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Faecal volatile organic compounds analysis using field asymmetric ion mobility spectrometry : non-invasive diagnostics in paediatric inflammatory bowel disease
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van Gaal, Nora, Lakenman, Rozanne, Covington, James A., Savage, Richard S., de Groot, Evelien, Bomers, Marije, Benninga, Marc, Mulder, Chris, de Boer, Nanne and de Meij, Tim (2017) Faecal volatile organic compounds analysis using field asymmetric ion mobility spectrometry : non-invasive diagnostics in paediatric inflammatory bowel disease. Journal of Breath Research, 12 (1). 016006. doi:10.1088/1752-7163/aa6f1d ISSN 1752-7163.
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WRAP-non-invasive-diagnostics-paediatric-Covington-2017.pdf - Accepted Version - Requires a PDF viewer. Download (813Kb) | Preview |
Official URL: http://dx.doi.org/10.1088/1752-7163/aa6f1d
Abstract
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains challenging to diagnose. Diagnostic work up carries a high burden, especially in paediatric patients, due to invasive endoscopic procedures. IBD is associated with alterations in intestinal microbiota composition. Faecal volatile organic compounds (VOCs) reflect gut microbiota composition. Aim of this study was to assess the diagnostic accuracy of faecal VOC profiling as non-invasive diagnostic biomarker for paediatric IBD.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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| Library of Congress Subject Headings (LCSH): | Inflammatory bowel diseases -- Diagnosis, Crohn's disease, Ulcerative colitis in children | ||||||||
| Journal or Publication Title: | Journal of Breath Research | ||||||||
| Publisher: | Institute of Physics Publishing Ltd. | ||||||||
| ISSN: | 1752-7163 | ||||||||
| Official Date: | 28 November 2017 | ||||||||
| Dates: |
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| Volume: | 12 | ||||||||
| Number: | 1 | ||||||||
| Article Number: | 016006 | ||||||||
| DOI: | 10.1088/1752-7163/aa6f1d | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 9 June 2017 | ||||||||
| Date of first compliant Open Access: | 25 April 2018 |
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