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Unconventional transport routes of soluble and membrane proteins and their role in developmental biology.
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Pompa, Andrea, De Marchis, Francesca, Pallotta, Maria Teresa, Benitez-Alfonso, Yoselin, Jones, Alexandra M., Schipper, Kerstin, Moreau, Kevin, Žárský, Viktor, Di Sansebastiano, Gian Pietro and Bellucci, Michele (2017) Unconventional transport routes of soluble and membrane proteins and their role in developmental biology. International Journal of Molecular Sciences, 18 (4). 703. doi:10.3390/ijms18040703
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Official URL: http://dx.doi.org/10.3390/ijms18040703
Abstract
Many proteins and cargoes in eukaryotic cells are secreted through the conventional secretory pathway that brings proteins and membranes from the endoplasmic reticulum to the plasma membrane, passing through various cell compartments, and then the extracellular space. The recent identification of an increasing number of leaderless secreted proteins bypassing the Golgi apparatus unveiled the existence of alternative protein secretion pathways. Moreover, other unconventional routes for secretion of soluble or transmembrane proteins with initial endoplasmic reticulum localization were identified. Furthermore, other proteins normally functioning in conventional membrane traffic or in the biogenesis of unique plant/fungi organelles or in plasmodesmata transport seem to be involved in unconventional secretory pathways. These alternative pathways are functionally related to biotic stress and development, and are becoming more and more important in cell biology studies in yeast, mammalian cells and in plants. The city of Lecce hosted specialists working on mammals, plants and microorganisms for the inaugural meeting on “Unconventional Protein and Membrane Traffic” (UPMT) during 4–7 October 2016. The main aim of the meeting was to include the highest number of topics, summarized in this report, related to the unconventional transport routes of protein and membranes.
| Item Type: | Journal Item | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history | ||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) | ||||||
| Library of Congress Subject Headings (LCSH): | Proteins -- Secretion -- Congresses, Eukaryotic cells -- Congresses, Cytology -- Congresses | ||||||
| Journal or Publication Title: | International Journal of Molecular Sciences | ||||||
| Publisher: | M D P I AG | ||||||
| ISSN: | 1422-0067 | ||||||
| Official Date: | 25 March 2017 | ||||||
| Dates: |
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| Date of first compliant deposit: | 15 June 2017 | ||||||
| Volume: | 18 | ||||||
| Number: | 4 | ||||||
| Article Number: | 703 | ||||||
| DOI: | 10.3390/ijms18040703 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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