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Brown fat depots in adult humans remain static in their locations on PET/CT despite changes in seasonality
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Jones, Terence A., Reddy, Narendra Lakshmana, Wayte, Sarah, Adesanya, Oludolapo, Dimitriadis, Georgios K., Hutchinson, Charles E. and Barber, T. M. (2017) Brown fat depots in adult humans remain static in their locations on PET/CT despite changes in seasonality. Physiological Report, 5 (11). e13284. ISSN 2051-817X.
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Official URL: https://doi.org/10.14814/phy2.13284
Abstract
Active brown adipose tissue (BAT) in humans has been demonstrated through use of positron emission tomography with 2-deoxy-2-(fluorine-18) fluoro-D-glucose integrated with computed tomography (18F-FDG PET/CT) scans. The aim of our study was to determine whether active human BAT depots shown on 18F-FDG PET/CT scans remain static in their location over time. This was a retrospective study. Adult human subjects (n = 15) who had had 18F-FDG PET/CT imaging (n = 38 scans in total) for clinical reasons were included on the basis of 18F-FDG uptake patterns consistent with BAT activity. For each subject, 18F-FDG BAT uptake pattern on serial 18F-FDG PET/CT images was compared to an index 18F-FDG PET/CT image with the largest demonstrable BAT volume. Object-based colocalization was expressed as Mander's correlation coefficient (where 1 = 100% overlap, 0 = no overlap). Distribution of 18F-FDG BAT activity over time and across multiple 18F-FDG BAT scans was equivalent in 60% (n = 9) of the subjects. The degree of consistency in the pattern of 18F-FDG BAT uptake in each subject over time was greater than expected by chance in 87% (n = 13) of the subjects (pair-wise agreement 75–100%, Fleiss’ κ 0.4–1). The degree of BAT colocalization on serial scans was greater than that expected by chance in 93% (n = 14) of the subjects (mean Mander's coefficient 0.81 ± 0.21 [95% CI]). To our knowledge, our study provides the most conclusive evidence to date to support the notion that active BAT depots in humans (volumes and activities of which were measured through use of 18F-FDG PET/CT scans) remain static in location over sustained periods.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QP Physiology R Medicine > R Medicine (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Physiological Report | ||||||
Publisher: | Wiley Periodicals | ||||||
ISSN: | 2051-817X | ||||||
Official Date: | 2 June 2017 | ||||||
Dates: |
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Volume: | 5 | ||||||
Number: | 11 | ||||||
Article Number: | e13284 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 15 June 2017 | ||||||
Date of first compliant Open Access: | 15 June 2017 | ||||||
Funder: | University of Warwick Strategic Impact Fund |
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