Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Associated illness severity in schizophrenia and diabetes mellitus : a systematic review

Tools
- Tools
+ Tools

Perry, Benjamin Ian, Salimkumar , Dhanya, Green, Daniel, Meakin, Anne, Gibson, Andrew J., Mahajan, Deepali, Tahir, Tayyeb and Singh, Swaran P. (2017) Associated illness severity in schizophrenia and diabetes mellitus : a systematic review. Psychiatry research, 256 . pp. 102-110. doi:10.1016/j.psychres.2017.06.027 ISSN 0165-1781.

[img]
Preview
PDF
WRAP-associated-illness-diabetes-review-Perry-2017.pdf - Accepted Version - Requires a PDF viewer.

Download (875Kb) | Preview
Official URL: http://dx.doi.org/10.1016/j.psychres.2017.06.027

Request Changes to record.

Abstract

Objective

We aimed to elucidate whether schizophrenia and type II diabetes mellitus may present with associated illness severity, in light of accumulating evidence to suggest both conditions have important shared inflammatory components with many shared inflammatory genetic factors.

Methods

We conducted a systematic review employing PRISMA criteria, searching EMBASE, Ovid MEDLINE, PsychInfo, Web of Science and Google Scholar to February 1st 2017, for clinical studies assessing schizophrenia severity alongside dysglycaemia. A narrative synthesis was employed to discuss and compare findings between studies.

Results

Eleven observational studies were included in the analysis. Ten presented evidence in support of an association between schizophrenia severity and dysglycaemia. This association appeared particularly strong regarding negative symptomatology and impaired cognitive function, between which there may be some overlap. Studies examining positive symptomatology returned mixed results.

Conclusion

Whilst study design varied amongst the included studies, the results suggest that further work examining the effect of hyperglycaemia on schizophrenia severity may be relevant, particularly longitudinal studies assessing negative symptomatology and cognitive function. To the authors’ knowledge, this is the first systematic review conducted to address this question.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Schizophrenia, Non-insulin-dependent diabetes, Inflammation, Systematic reviews (Medical research)
Journal or Publication Title: Psychiatry research
Publisher: Elsevier Ireland Ltd.
ISSN: 0165-1781
Official Date: October 2017
Dates:
DateEvent
October 2017Published
13 June 2017Available
10 June 2017Accepted
Volume: 256
Page Range: pp. 102-110
DOI: 10.1016/j.psychres.2017.06.027
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 15 June 2017
Date of first compliant Open Access: 13 June 2018

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us