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Associated illness severity in schizophrenia and diabetes mellitus : a systematic review
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Perry, Benjamin Ian, Salimkumar , Dhanya, Green, Daniel, Meakin, Anne, Gibson, Andrew J., Mahajan, Deepali, Tahir, Tayyeb and Singh, Swaran P. (2017) Associated illness severity in schizophrenia and diabetes mellitus : a systematic review. Psychiatry research, 256 . pp. 102-110. doi:10.1016/j.psychres.2017.06.027 ISSN 0165-1781.
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Official URL: http://dx.doi.org/10.1016/j.psychres.2017.06.027
Abstract
Objective
We aimed to elucidate whether schizophrenia and type II diabetes mellitus may present with associated illness severity, in light of accumulating evidence to suggest both conditions have important shared inflammatory components with many shared inflammatory genetic factors.
Methods
We conducted a systematic review employing PRISMA criteria, searching EMBASE, Ovid MEDLINE, PsychInfo, Web of Science and Google Scholar to February 1st 2017, for clinical studies assessing schizophrenia severity alongside dysglycaemia. A narrative synthesis was employed to discuss and compare findings between studies.
Results
Eleven observational studies were included in the analysis. Ten presented evidence in support of an association between schizophrenia severity and dysglycaemia. This association appeared particularly strong regarding negative symptomatology and impaired cognitive function, between which there may be some overlap. Studies examining positive symptomatology returned mixed results.
Conclusion
Whilst study design varied amongst the included studies, the results suggest that further work examining the effect of hyperglycaemia on schizophrenia severity may be relevant, particularly longitudinal studies assessing negative symptomatology and cognitive function. To the authors’ knowledge, this is the first systematic review conducted to address this question.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Schizophrenia, Non-insulin-dependent diabetes, Inflammation, Systematic reviews (Medical research) | ||||||||
| Journal or Publication Title: | Psychiatry research | ||||||||
| Publisher: | Elsevier Ireland Ltd. | ||||||||
| ISSN: | 0165-1781 | ||||||||
| Official Date: | October 2017 | ||||||||
| Dates: |
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| Volume: | 256 | ||||||||
| Page Range: | pp. 102-110 | ||||||||
| DOI: | 10.1016/j.psychres.2017.06.027 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 15 June 2017 | ||||||||
| Date of first compliant Open Access: | 13 June 2018 |
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