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Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations
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Farrell, Frederick, Gralka, Matti, Hallatschek, Oskar and Waclaw, Bartlomiej (2017) Mechanical interactions in bacterial colonies and the surfing probability of beneficial mutations. Journal of the Royal Society, Interface, 14 (131). 20170073. doi:10.1098/rsif.2017.0073 ISSN 1742-5662.
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Official URL: https://doi.org/10.1098/rsif.2017.0073
Abstract
Bacterial conglomerates such as biofilms and microcolonies are ubiquitous in nature and play an important role in industry and medicine. In contrast to well-mixed cultures routinely used in microbial research, bacteria in a microcolony interact mechanically with one another and with the substrate to which they are attached. Here, we use a computer model of a microbial colony of rod-shaped cells to investigate how physical interactions between cells determine their motion in the colony and how this affects biological evolution. We show that the probability that a faster-growing mutant 'surfs' at the colony's frontier and creates a macroscopic sector depends on physical properties of cells (shape, elasticity and friction). Although all these factors contribute to the surfing probability in seemingly different ways, their effects can be summarized by two summary statistics that characterize the front roughness and cell alignment. Our predictions are confirmed by experiments in which we measure the surfing probability for colonies of different front roughness. Our results show that physical interactions between bacterial cells play an important role in biological evolution of new traits, and suggest that these interactions may be relevant to processes such as de novo evolution of antibiotic resistance.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QR Microbiology | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Bacteria -- Evolution, Biofilms, Microbial aggregation, Bacteria -- Motility, Cells -- Mechanical properties | |||||||||||||||
Journal or Publication Title: | Journal of the Royal Society, Interface | |||||||||||||||
Publisher: | Royal Society | |||||||||||||||
ISSN: | 1742-5662 | |||||||||||||||
Official Date: | 7 June 2017 | |||||||||||||||
Dates: |
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Volume: | 14 | |||||||||||||||
Number: | 131 | |||||||||||||||
Article Number: | 20170073 | |||||||||||||||
DOI: | 10.1098/rsif.2017.0073 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Reuse Statement (publisher, data, author rights): | ||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 13 July 2018 | |||||||||||||||
Date of first compliant Open Access: | 13 July 2018 | |||||||||||||||
RIOXX Funder/Project Grant: |
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