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Cells respond to mechanical stress by rapid disassembly of caveolae
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Sinha, Bidisha, Köster, Darius, Ruez, Richard, Gonnord, Pauline, Bastiani, Michele, Abankwa, Daniel, Stan, Radu V., Butler-Browne, Gillian, Vedie, Benoit, Johannes, Ludger, Morone, Nobuhiro, Parton, Robert G., Raposo, Graça, Sens, Pierre, Lamaze, Christophe and Nassoy, Pierre (2011) Cells respond to mechanical stress by rapid disassembly of caveolae. Cell, 144 (3). pp. 402-413. doi:10.1016/j.cell.2010.12.031 ISSN 0092-8674.
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Official URL: http://dx.doi.org/10.1016/j.cell.2010.12.031
Abstract
The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Cell | ||||
Publisher: | Cell Press | ||||
ISSN: | 0092-8674 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | 144 | ||||
Number: | 3 | ||||
Page Range: | pp. 402-413 | ||||
DOI: | 10.1016/j.cell.2010.12.031 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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