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Post-admission outcomes of participants in the PARAMEDIC trial : a cluster randomised trial of mechanical or manual chest compressions
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Ji, Chen, Lall, Ranjit, Quinn, T., Kaye, Charlotte, Haywood, Kirstie L., Horton, Jessica, Gordon, Victoria, Deakin, C. D., Pocock, H., Carson, A., Smyth, Michael A., Rees, N., Kyee, Han, Byers, S., Brace-McDonnell, Samantha J., Gates, Simon and Perkins, Gavin D. (2017) Post-admission outcomes of participants in the PARAMEDIC trial : a cluster randomised trial of mechanical or manual chest compressions. Resuscitation, 118 . pp. 82-88. ISSN 0300-9572.
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WRAP-post-admission-outcomes-participants-PARAMEDIC-trial-Perkins-2017.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (972Kb) | Preview |
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WRAP-supplementarymaterial-2017.pdf - Accepted Version - Requires a PDF viewer. Download (205Kb) | Preview |
Official URL: https://doi.org/10.1016/j.resuscitation.2017.06.02...
Abstract
Background:
The PARAMEDIC cluster randomised trial evaluated the LUCAS mechanical chest compression device, and did not find evidence that use of mechanical chest compression led to an improvement in survival at 30 days. This paper reports patient outcomes from admission to hospital to 12 months after randomisation.
Methods:
Information about hospital length of stay and intensive care management was obtained through linkage with Hospital Episode Statistics and the Intensive Care National Audit and Research Centre. Patients surviving to hospital discharge were approached to complete questionnaires (SF-12v2, EQ-5D, MMSE, HADS and PTSD-CL) at 90 days and 12 months. The study is registered with Current Controlled Trials, number ISRCTN08233942.
Results:
377 patients in the LUCAS arm and 658 patients in the manual chest compression were admitted to hospital. Hospital and intensive care length of stay were similar. Long term follow-up assessments were limited by poor response rates (53.7% at 3 months and 55.6% at 12 months). Follow-up rates were lower in those with worse neurological function. Among respondents, long term health related quality of life outcomes and emotional well-being was similar between groups. Cognitive function, measured by MMSE, was marginally lower in the LUCAS arm mean 26.9 (SD 3.7) compared to control mean 28.0 (SD 2.3), adjusted mean difference −1.5 (95% CI −2.6 to −0.4).
Conclusion:
There were no clinically important differences identified in outcomes at long term follow-up between those allocated to the mechanical chest compression compared to those receiving manual chest compression.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Resuscitation | ||||||||
| Publisher: | Elsevier Ireland Ltd | ||||||||
| ISSN: | 0300-9572 | ||||||||
| Official Date: | September 2017 | ||||||||
| Dates: |
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| Volume: | 118 | ||||||||
| Page Range: | pp. 82-88 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 28 June 2017 | ||||||||
| Date of first compliant Open Access: | 22 January 2018 | ||||||||
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