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Novel chemical probes for the investigation of nonribosomal peptide assembly
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Ho, Y. T. Candace, Leng, Daniel J., Ghiringhelli, Francesca, Wilkening, Ina, Bushell, Dexter P., Köstner, Otto, Riva, Elena, Havemann, Judith, Passarella, Daniele and Tosin, Manuela (2017) Novel chemical probes for the investigation of nonribosomal peptide assembly. Chemical Communications, 53 (52). pp. 7088-7091. doi:10.1039/c7cc02427d ISSN 1359-7345.
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WRAP-chemical-probes-nonribosomal-peptide-assembly-Toisin-2017.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2143Kb) | Preview |
Official URL: http://doi.org/10.1039/c7cc02427d
Abstract
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Library of Congress Subject Headings (LCSH): | Peptides , Enzymology, Polyketides--Synthesis | ||||||||
| Journal or Publication Title: | Chemical Communications | ||||||||
| Publisher: | Royal Society of Chemistry | ||||||||
| ISSN: | 1359-7345 | ||||||||
| Official Date: | 27 June 2017 | ||||||||
| Dates: |
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| Volume: | 53 | ||||||||
| Number: | 52 | ||||||||
| Page Range: | pp. 7088-7091 | ||||||||
| DOI: | 10.1039/c7cc02427d | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router. | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 17 August 2017 | ||||||||
| Date of first compliant Open Access: | 17 August 2017 | ||||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), ERASMUS (Organization), Marie Curie Intra-European Fellowship (IEF), Seventh Framework Programme (European Commission) (FP7), University of Warwick Institute of Advanced Study Scholarship, COST Action | ||||||||
| Grant number: | BB/J007250/1 (BBSRC), CM1407 (COST Action) |
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