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Relationship between subjective and actigraphy-measured sleep in 237 patients with metastatic colorectal cancer
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Palesh, Oxana, Haitz, Karyn, Lévi, Francis A., Bjarnason, Georg A., Deguzman, Carl, Alizeh, Igbal, Ulusakarya, Ayhan, Packer, Mary Melissa and Innominato, Pasquale F. (2017) Relationship between subjective and actigraphy-measured sleep in 237 patients with metastatic colorectal cancer. Quality of Life Research, 26 (10). pp. 2783-2791. doi:10.1007/s11136-017-1617-2 ISSN 0962-9343.
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Official URL: http://dx.doi.org/10.1007/s11136-017-1617-2
Abstract
Objective:
Patients with cancers frequently experience sleep and circadian dysfunction. To date, only a few studies have used both a questionnaire and actigraphy for concomitant evaluation of sleep and circadian function in patients with cancer. We sought to evaluate objective sleep and circadian parameters in metastatic colon cancer (MCC) patients and their associations with symptoms and quality of life (QOL).
Methods:
Patients reported subjective sleep problems on the EORTC QLQ-C30. Sleep and circadian parameters were calculated using a wrist-actigraph that patients wore for 72 h.
Results:
237 Patients with MCC (mean age: 60.4 years; range: 20.7–77.6; Male/Female ratio: 1.66) participated in this cross-sectional study. Subjective sleep problems were reported by 63.4% of patients (S+). No differences in any sleep parameters (sleep efficiency, sleep latency, total sleep time, total time in bed, wake after sleep onset, activity bathyphase) were observed between S+ and S− patients. However, S+ patients displayed a significantly worse circadian function than S− patients (96.4 vs 98.1%; p = 0.005). The presence of poor subjective sleep and objective circadian dysfunction negatively affected symptoms and QOL domains (p = 0.038).
Conclusions:
Subjective report of sleep problems was not associated with worse objectively measured sleep parameters in patients with MCC although it was associated with disrupted circadian rest-activity rhythm and poorer QOL. These findings coincide with prior research in cancer patients in that an inconsistent relationship exists between subjective and objective sleep measurements on some sleep domains. This study supports the value of coupled evaluation of self-reported and objective measures of sleep and circadian function in cancer patients.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Quality of Life Research | ||||||||
| Publisher: | Springer Netherlands | ||||||||
| ISSN: | 0962-9343 | ||||||||
| Official Date: | October 2017 | ||||||||
| Dates: |
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| Volume: | 26 | ||||||||
| Number: | 10 | ||||||||
| Page Range: | pp. 2783-2791 | ||||||||
| DOI: | 10.1007/s11136-017-1617-2 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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