Interactions between myeloma and endothelial cells and the effects of thalidomide and its analogues
UNSPECIFIED (2002) Interactions between myeloma and endothelial cells and the effects of thalidomide and its analogues. In: 7th Annual Meeting of the European-Haematology-Association, FLORENCE, ITALY, JUN 06-09, 2002. Published in: 7TH ANNUAL MEETING OF THE EUROPEAN HAEMATOLOGY ASSOCIATION pp. 263-266.Full text not available from this repository.
Modelling the situation observed in vivo, we examined the effects of thalidomide and its analogues in co-cultures of myeloma and endothelial cells. It was found that myeloma cells in co-culture had significantly lower levels of CC-10004- and CC-1088-induced apoptosis than those cultured alone. Interestingly, basal apoptosis was also lower in RPMI-8226/S co-cultured with endothelial cells compared to myeloma cell culture. Our data suggest that myeloma/endothelial cell interactions in co-culture have a significant protective effect on both basal and drug-induced levels of apoptosis in myeloma cells.
|Item Type:||Conference Item (UNSPECIFIED)|
|Subjects:||R Medicine > RB Pathology|
|Journal or Publication Title:||7TH ANNUAL MEETING OF THE EUROPEAN HAEMATOLOGY ASSOCIATION|
|Publisher:||MEDIMOND S R L|
|Number of Pages:||4|
|Page Range:||pp. 263-266|
|Title of Event:||7th Annual Meeting of the European-Haematology-Association|
|Location of Event:||FLORENCE, ITALY|
|Date(s) of Event:||JUN 06-09, 2002|
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