UNSPECIFIED (2002) Interactions between myeloma and endothelial cells and the effects of thalidomide and its analogues. In: 7th Annual Meeting of the European-Haematology-Association, JUN 06-09, 2002, FLORENCE, ITALY.

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Abstract

Modelling the situation observed in vivo, we examined the effects of thalidomide and its analogues in co-cultures of myeloma and endothelial cells. It was found that myeloma cells in co-culture had significantly lower levels of CC-10004- and CC-1088-induced apoptosis than those cultured alone. Interestingly, basal apoptosis was also lower in RPMI-8226/S co-cultured with endothelial cells compared to myeloma cell culture. Our data suggest that myeloma/endothelial cell interactions in co-culture have a significant protective effect on both basal and drug-induced levels of apoptosis in myeloma cells.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	R Medicine > RB Pathology
Journal or Publication Title:	7TH ANNUAL MEETING OF THE EUROPEAN HAEMATOLOGY ASSOCIATION
Publisher:	MEDIMOND S R L
ISBN:	88-323-2606-X
Date:	2002
Number of Pages:	4
Page Range:	pp. 263-266
Publication Status:	Published
Title of Event:	7th Annual Meeting of the European-Haematology-Association
Location of Event:	FLORENCE, ITALY
Date(s) of Event:	JUN 06-09, 2002
URI:	http://wrap.warwick.ac.uk/id/eprint/8972

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