The Library
The impact of current infection levels on the cost-benefit of vaccination
Tools
Tools
Tools
Keeling, Matthew James, Broadfoot, Katherine and Datta, Samik (2017) The impact of current infection levels on the cost-benefit of vaccination. Epidemics, 21 . pp. 56-62. doi:10.1016/j.epidem.2017.06.004 ISSN 1755-4365.
|
PDF
WRAP-impact-current-infection-benefit-vaccination-Keeling-2017.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2305Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.epidem.2017.06.004
Abstract
When considering a new vaccine program or modifying an existing one, economic cost-benefit analysis, underpinned by predictive epidemiological modelling, is a key component. This analysis is intimately linked to the willingness to pay for additional QALYs (quality-adjusted life-years) gained; currently in England and Wales a health program is economically viable if the cost per QALY gained is less than £ 20,000, and models are often used to assess if a vaccine program is likely to fall below this threshold cost. Before a program begins, infection levels are generally high and therefore vaccination may be expected to have substantial effects and therefore will often be economically viable. However, once a program is established, and infection rates are lower, it might be expected that a re-evaluation of the program (using current incidence information) will show it to be less cost-effective. This is the scenario we examine here with analytical tools and simple ODE models. Surprisingly we show that in most cases the benefits from maintaining an existing vaccination program are at least equal to those of starting the program initially, and in the majority of scenarios the differences between the two are minimal. In practical terms, this is an extremely helpful finding, allowing us to assert that the action of immunising individuals does not de-value the vaccination program.
| Item Type: | Journal Article | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
|||||||||
| Library of Congress Subject Headings (LCSH): | Vaccination -- Cost effectiveness -- Mathematical models | |||||||||
| Journal or Publication Title: | Epidemics | |||||||||
| Publisher: | Elsevier BV | |||||||||
| ISSN: | 1755-4365 | |||||||||
| Official Date: | December 2017 | |||||||||
| Dates: |
|
|||||||||
| Volume: | 21 | |||||||||
| Page Range: | pp. 56-62 | |||||||||
| DOI: | 10.1016/j.epidem.2017.06.004 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 11 July 2017 | |||||||||
| Date of first compliant Open Access: | 11 July 2017 | |||||||||
| Funder: | Great Britain. Department of Health (DoH), Medical Research Council (Great Britain) (MRC) | |||||||||
| Grant number: | Grant number 027/0089 (DoH) | |||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
