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Some assembly required : redefining the mitotic checkpoint
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Meadows, John C. and Millar, Jonathan B. A. (2017) Some assembly required : redefining the mitotic checkpoint. Molecular & Cellular Oncology, 4 (6). e1314238. doi:10.1080/23723556.2017.1314238
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Official URL: http://dx.doi.org/10.1080/23723556.2017.1314238
Abstract
The spindle assembly checkpoint (also known as the spindle or mitotic checkpoint) is a surveillance system that ensures fidelity of chromosome segregation. Here we suggest, in light of historical and more recent evidence, that this signaling system monitors kinetochore attachment and spindle assembly by two distinct, but functionally overlapping, pathways.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | |||||||||
| Divisions: | Other > Institute of Advanced Study Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Tumours, Spindle (Cell division), Aneuploidy, Protista | |||||||||
| Journal or Publication Title: | Molecular & Cellular Oncology | |||||||||
| Publisher: | Taylor & Francis Inc. | |||||||||
| ISSN: | 2372-3556 | |||||||||
| Official Date: | 4 October 2017 | |||||||||
| Dates: |
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| Volume: | 4 | |||||||||
| Number: | 6 | |||||||||
| Article Number: | e1314238 | |||||||||
| DOI: | 10.1080/23723556.2017.1314238 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| Funder: | University of Warwick. Institute of Advanced Study (IAS), Medical Research Council (Great Britain) (MRC) | |||||||||
| Grant number: | MR/K001000/1 (MRC) | |||||||||
| RIOXX Funder/Project Grant: |
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