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Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV

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Xie, Ming-jin, Zhu, Ming-rong, Lu, Chun-Mei, Jin, Yi, Gao, Li-Hui, Li, Ling, Zhou, Jie, Li, Fan-fang, Zhao, Qi Hua, Liu, Hong-Ke, Sadler, P. J. and Sanchez-Cano, Carlos (2017) Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry, 175 . pp. 29-35. doi:10.1016/j.jinorgbio.2017.06.014

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Official URL: https://doi.org/10.1016/j.jinorgbio.2017.06.014

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Abstract

Two oxidovanadium(IV) complexes carrying Schiff base ligands obtained from the condensation of 4,5-dichlorobenzene-1,2-diamine and salicylaldehyde derivatives were synthesised and characterised, including their X-ray crystallographic structures. They were evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes. These compounds were moderate inhibitors of DPP-IV, with IC50 values of ca. 40 μM. In vivo tests showed that complexes 1 and 2 could lower significantly the level of glucose in the blood of alloxan-diabetic mice at doses of 22.5 mg V·kg− 1 and 29.6 mg V·kg− 1, respectively. Moreover, molecular modeling studies suggested that the oxidovanadium complexes 1 and 2 could fit well into the active-site cleft of the kinase domain of DPP-IV. To the best of our knowledge, this is the first report of vanadium complexes capable of inhibiting DPP-IV.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science > Chemistry
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Enzyme inhibitors, Schiff bases, Vanadium, Non-insulin-dependent diabetes -- Treatment
Journal or Publication Title: Journal of Inorganic Biochemistry
Publisher: Elsevier Science Inc
ISSN: 0162-0134
Official Date: October 2017
Dates:
DateEvent
October 2017Published
29 June 2017Available
23 June 2017Accepted
Date of first compliant deposit: 27 July 2017
Volume: 175
Page Range: pp. 29-35
DOI: 10.1016/j.jinorgbio.2017.06.014
Status: Peer Reviewed
Publication Status: Published
Publisher Statement: ** Embargo End Date: 14-07-2017 ** From Crossref via Jisc Publications Router. ** Licence for this article starting on 14-07-2017: http://creativecommons.org/licenses/by/4.0/
Access rights to Published version: Restricted or Subscription Access
Funder: Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Yunnan Sheng (China), European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC)
Grant number: 21161022, 21061016, 81260502, 21420102002 (NSFC), 2001CI002 (Yunnan Sheng (China)), 247450 (ERC), EP/F034210/1 (EPSRC)

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