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Towards the stabilisation of enzymes via the synthesis of protein-polymer conjugates.
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Hill, Alice (2017) Towards the stabilisation of enzymes via the synthesis of protein-polymer conjugates. PhD thesis, University of Warwick.
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WRAP_Theses_Hill_2017.pdf - Submitted Version - Requires a PDF viewer. Download (8Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b3072636~S15
Abstract
This thesis explores the use of protein-polymer conjugates to enhance the stability of various enzymatic species.
Chapter 1 gives an overview of the current literature covering mechanisms of enzyme denaturation and various approaches to enhance stability of enzymatic species.
Chapter 2 evaluates the synthesis of protein macro-initiators from α-chymotrypsin and the ability to tune the initiator grafting density by employing control of pH and concentration.
Chapter 3 examines the production of protein-polymer conjugates from α-chymotrypsin utilising atom transfer radical polymerisations with a hydrophilic monomer, glycerol methacrylate, and investigates the effects of altering the polymeric grafting densities on enzyme stability.
Chapter 4 investigates the functionality and architecture of the grafted polymer on the surface of α-Chymotrypsin and the subsequent effects on both activity and stability of the protein-polymer conjugate.
Chapter 5 discusses the challenges of employing the chemistries used to synthesise both protein macro-initiators and protein-polymer conjugates on enzymes specific to laundry applications.
| Item Type: | Thesis or Dissertation (PhD) | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Enzymes -- Stability, Enzymes -- Industrial applications, Polymers, Polymerization | ||||
| Official Date: | January 2017 | ||||
| Dates: |
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| Institution: | University of Warwick | ||||
| Theses Department: | Department of Chemistry | ||||
| Thesis Type: | PhD | ||||
| Publication Status: | Unpublished | ||||
| Supervisor(s)/Advisor: | O'Reilly, Rachel K. | ||||
| Sponsors: | Unilever (Firm) | ||||
| Format of File: | |||||
| Extent: | xxxix, 284 leaves : illustrations, charts | ||||
| Language: | eng |
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