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Towards the stabilisation of enzymes via the synthesis of protein-polymer conjugates.

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Hill, Alice (2017) Towards the stabilisation of enzymes via the synthesis of protein-polymer conjugates. PhD thesis, University of Warwick.

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Official URL: http://webcat.warwick.ac.uk/record=b3072636~S15

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Abstract

This thesis explores the use of protein-polymer conjugates to enhance the stability of various enzymatic species.

Chapter 1 gives an overview of the current literature covering mechanisms of enzyme denaturation and various approaches to enhance stability of enzymatic species.

Chapter 2 evaluates the synthesis of protein macro-initiators from α-chymotrypsin and the ability to tune the initiator grafting density by employing control of pH and concentration.

Chapter 3 examines the production of protein-polymer conjugates from α-chymotrypsin utilising atom transfer radical polymerisations with a hydrophilic monomer, glycerol methacrylate, and investigates the effects of altering the polymeric grafting densities on enzyme stability.

Chapter 4 investigates the functionality and architecture of the grafted polymer on the surface of α-Chymotrypsin and the subsequent effects on both activity and stability of the protein-polymer conjugate.

Chapter 5 discusses the challenges of employing the chemistries used to synthesise both protein macro-initiators and protein-polymer conjugates on enzymes specific to laundry applications.

Item Type: Thesis or Dissertation (PhD)
Subjects: Q Science > QD Chemistry
Library of Congress Subject Headings (LCSH): Enzymes -- Stability, Enzymes -- Industrial applications, Polymers, Polymerization
Official Date: January 2017
Dates:
DateEvent
January 2017Submitted
Institution: University of Warwick
Theses Department: Department of Chemistry
Thesis Type: PhD
Publication Status: Unpublished
Supervisor(s)/Advisor: O'Reilly, Rachel K.
Sponsors: Unilever (Firm)
Format of File: pdf
Extent: xxxix, 284 leaves : illustrations, charts
Language: eng

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