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Intracellular cargo transport by kinesin-3 motors
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Siddiqui, Nida and Straube, Anne (2017) Intracellular cargo transport by kinesin-3 motors. Biochemistry (Moscow), 82 (7). pp. 803-815. doi:10.1134/s0006297917070057 ISSN 1608-3040.
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Official URL: http://doi.org/10.1134/s0006297917070057
Abstract
Intracellular transport along microtubules enables cellular cargoes to efficiently reach the extremities of large, eukaryotic cells. While it would take more than 200 years for a small vesicle to diffuse from the cell body to the growing tip of a one-meter long axon, transport by a kinesin allows delivery in one week. It is clear from this example that the evolution of intracellular transport was tightly linked to the development of complex and macroscopic life forms. The human genome encodes 45 kinesins, 8 of those belonging to the family of kinesin-3 organelle transporters that are known to transport a variety of cargoes towards the plus end of microtubules. However, their mode of action, their tertiary structure, and regulation are controversial. In this review, we summarize the latest developments in our understanding of these fascinating molecular motors.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||
| Library of Congress Subject Headings (LCSH): | Microtubules, Kinesin, Eukaryotic cells | ||||
| Journal or Publication Title: | Biochemistry (Moscow) | ||||
| Publisher: | Pleiades Publishing | ||||
| ISSN: | 1608-3040 | ||||
| Official Date: | 23 July 2017 | ||||
| Dates: |
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| Volume: | 82 | ||||
| Number: | 7 | ||||
| Page Range: | pp. 803-815 | ||||
| DOI: | 10.1134/s0006297917070057 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Reuse Statement (publisher, data, author rights): | ** From Springer Nature via Jisc Publications Router. ** History: ** received: 01-02-2017 ** rev-recd: 11-04-2017 ** ppub: 01-07-2017 ** epub: 23-07-2017 ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Date of first compliant deposit: | 28 July 2017 | ||||
| Date of first compliant Open Access: | 28 July 2017 | ||||
| Funder: | Lister Institute of Preventive Medicine, Wellcome Trust (London, England), University of Warwick Chancellor’s Interational Scholarship | ||||
| Grant number: | 200870/Z/16/Z (Wellcome Trust (London, England)) |
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